PMID- 11281364
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20190826
IS  - 0014-2972 (Print)
IS  - 0014-2972 (Linking)
VI  - 30 Suppl 3
DP  - 2000 Dec
TI  - Intra-adrenal regulation of androgen synthesis.
PG  - 28-33
AB  - The adrenal cortex encloses the neuroendocrine medulla and is itself subdivided 
      into three distinct zones, each having a specific function and regulation. While 
      the glomerulosa and the fasciculata control vital systems of mineral and energy 
      supply, which are stringently regulated by higher control factors, the function 
      of the reticularis is less clear, beyond supplying a pool of weak androgens, and 
      consequently we do not understand its redundant regulation. The following 
      questions need to be answered: 1. How is the formation of dehydroepiandrosterone 
      (DHEA) and androstenedione differently regulated from glucocorticoid synthesis in 
      normally functioning adrenals? 2. How might growth factors, which increase 
      prepubertally, prime the adrenarche? 3. The regulation of the 17/20-lyase enzyme 
      activity is one of the key factors of adrenal androgen secretion (review [2]). 
      How can the two activities of the P450c17 enzyme be differently regulated in the 
      same cell in a developmentally dependent fashion? This review focuses on the 
      intra-adrenal growth factor system and on the role of 17/20-lyase regulation, as 
      well as on their possible interactions. The increase of activity of the 
      17/20-lyase enzymatic activity is necessary for the rise of C19 steroids, while 
      the relative increase of formation of DHEA is only possible in the presence of a 
      low 3beta-hydroxysteroid-dehydrogenase (3betaHSD) activity.
FAU - l'Allemand, D
AU  - l'Allemand D
AD  - Department of Paediatrics, Humboldt University, Berlin, Germany.
FAU - Biason-Lauber, A
AU  - Biason-Lauber A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Androgens)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase)
SB  - IM
MH  - Adrenal Glands/*metabolism
MH  - Adrenocorticotropic Hormone/pharmacology
MH  - Androgens/*biosynthesis
MH  - Animals
MH  - Humans
MH  - Insulin-Like Growth Factor I/pharmacology
MH  - Steroid 17-alpha-Hydroxylase/metabolism/physiology
RF  - 37
EDAT- 2001/04/03 10:00
MHDA- 2001/06/08 10:01
CRDT- 2001/04/03 10:00
PHST- 2001/04/03 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/04/03 10:00 [entrez]
AID - 10.1046/j.1365-2362.2000.0300s3028.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2000 Dec;30 Suppl 3:28-33. doi: 
      10.1046/j.1365-2362.2000.0300s3028.x.