PMID- 11281511
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20191104
IS  - 1095-0680 (Print)
IS  - 1095-0680 (Linking)
VI  - 17
IP  - 1
DP  - 2001 Mar
TI  - ECS-Induced mossy fiber sprouting and BDNF expression are attenuated by ketamine 
      pretreatment.
PG  - 27-32
AB  - Recent evidence suggests hippocampal and possibly cortical atrophy is associated 
      with major depression. Chronic electroconvulsive seizures (ECS) induce 
      brain-derived neurotrophic factor (BDNF) expression and sprouting of the mossy 
      fiber pathway in the hippocampus, effects that may be related to 
      electroconvulsive therapy's (ECT) mechanism of action. The objective of this 
      study was to investigate the role of NMDA (N-methyl-D-aspartate) receptor in 
      mediating the ECS-induced mossy fiber sprouting and BDNF expression. Timm 
      histochemistry and in situ hybridization methodologies were used to determine the 
      effect of pretreatment with ketamine, an NMDA antagonist, on ECS-induced 
      sprouting and BDNF expression. The results demonstrate the ability of ketamine 
      pretreatment to attenuate ECS-induced sprouting in the dentate gyrus and BDNF 
      expression in the medial prefrontal cortex and the dentate gyrus. In addition, we 
      found a significant decrease in seizure duration with ketamine pretreatment. 
      These data suggest that NMDA receptor activation contributes to both the 
      regulation of neurotrophic factor expression and the morphological changes 
      associated with seizure activity. However, other effects resulting from shortened 
      seizure duration and seizure intensity cannot be excluded. These findings are of 
      increasing interest, as they relate to the use of ECT in the treatment of 
      depression, and the specific anesthetic agents that are used.
FAU - Chen, A C
AU  - Chen AC
AD  - Abraham Ribicoff Research Facilities, Yale University School of Medicine, 
      Connecticut Mental Health Center, New Haven 06508, USA.
FAU - Shin, K H
AU  - Shin KH
FAU - Duman, R S
AU  - Duman RS
FAU - Sanacora, G
AU  - Sanacora G
LA  - eng
GR  - MH25643/MH/NIMH NIH HHS/United States
GR  - MH45481/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Electroconvulsive Therapy/*adverse effects
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Ketamine/*pharmacology
MH  - Male
MH  - Mossy Fibers, Hippocampal/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/physiology
EDAT- 2001/04/03 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/04/03 10:00
PHST- 2001/04/03 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/04/03 10:00 [entrez]
AID - 10.1097/00124509-200103000-00006 [doi]
PST - ppublish
SO  - J ECT. 2001 Mar;17(1):27-32. doi: 10.1097/00124509-200103000-00006.