PMID- 11282168
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 115
IP  - 1-2
DP  - 2001 Apr 2
TI  - Characterization of the human T cell response against the neuronal protein 
      synapsin in patients with multiple sclerosis.
PG  - 176-81
AB  - Although multiple sclerosis (MS) is considered primarily as a demyelinating 
      disease, neuronal damage is abundant and correlates with the neurological 
      deficit. Therefore, we investigated the frequency and characteristics of human T 
      cells specific for synapsin-a neuronal protein highly conserved among species. 
      Synapsin specific T cell responses were detected at a frequency similar to that 
      of MBP specific T cells in MS patients, one patient with acute demyelinating 
      encephalomyelitis (ADEM) and controls. Long-term T cell lines specific for 
      synapsin exhibited a CD3(+), CD4(+), CD8(-) phenotype and produced high amounts 
      of tumor-necrosis-factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) after 
      antigen specific stimulation, whereas lymphotoxin (LT), interleukin-4 (IL-4) and 
      interleukin-10 (IL-10) were detectable in smaller quantities.
FAU - Polak, T
AU  - Polak T
AD  - Department of Neurology, Georg-August-University, Robert-Koch-Str. 40, 37075, 
      Gottingen, Germany.
FAU - Schlaf, G
AU  - Schlaf G
FAU - Scholl, U
AU  - Scholl U
FAU - Krome-Cesar, C
AU  - Krome-Cesar C
FAU - Mader, M
AU  - Mader M
FAU - Felgenhauer, K
AU  - Felgenhauer K
FAU - Weber, F
AU  - Weber F
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Synapsins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Acute Disease
MH  - CD3 Complex/biosynthesis
MH  - CD4 Antigens/biosynthesis
MH  - Cell Line
MH  - Dose-Response Relationship, Immunologic
MH  - Encephalomyelitis, Acute Disseminated/immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-10/biosynthesis
MH  - Interleukin-4/biosynthesis
MH  - Lymphotoxin-alpha/biosynthesis
MH  - Multiple Sclerosis/*immunology
MH  - Myelin Basic Protein/immunology
MH  - Synapsins/*immunology
MH  - T-Lymphocytes/cytology/*immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2001/04/03 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/04/03 10:00
PHST- 2001/04/03 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/04/03 10:00 [entrez]
AID - S016557280100251X [pii]
AID - 10.1016/s0165-5728(01)00251-x [doi]
PST - ppublish
SO  - J Neuroimmunol. 2001 Apr 2;115(1-2):176-81. doi: 10.1016/s0165-5728(01)00251-x.