PMID- 11283156
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20220408
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 193
IP  - 7
DP  - 2001 Apr 2
TI  - B7-DC, a new dendritic cell molecule with potent costimulatory properties for T 
      cells.
PG  - 839-46
AB  - Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell 
      stimulatory capacity, direct the activation and differentiation of T cells by 
      providing costimulatory signals. As such, they are critical regulators of both 
      natural and vaccine-induced immune responses. A new B7 family member, B7-DC, 
      whose expression is highly restricted to DCs, was identified among a library of 
      genes differentially expressed between DCs and activated macrophages. B7-DC fails 
      to bind the B7.1/2 receptors CD28 and cytotoxic T lymphocyte-associated antigen 
      (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. B7-DC costimulates T 
      cell proliferation more efficiently than B7.1 and induces a distinct pattern of 
      lymphokine secretion. In particular, B7-DC strongly costimulates interferon gamma 
      but not interleukin (IL)-4 or IL-10 production from isolated naive T cells. These 
      properties of B7-DC may account for some of the unique activity of DCs, such as 
      their ability to initiate potent T helper cell type 1 responses.
FAU - Tseng, S Y
AU  - Tseng SY
AD  - Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland 21205, USA.
FAU - Otsuji, M
AU  - Otsuji M
FAU - Gorski, K
AU  - Gorski K
FAU - Huang, X
AU  - Huang X
FAU - Slansky, J E
AU  - Slansky JE
FAU - Pai, S I
AU  - Pai SI
FAU - Shalabi, A
AU  - Shalabi A
FAU - Shin, T
AU  - Shin T
FAU - Pardoll, D M
AU  - Pardoll DM
FAU - Tsuchiya, H
AU  - Tsuchiya H
LA  - eng
SI  - GENBANK/AF142780
SI  - GENBANK/AF329193
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Surface)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (B7-1 Antigen)
RN  - 0 (CD28 Antigens)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (PDCD1LG2 protein, human)
RN  - 0 (Pdcd1 protein, mouse)
RN  - 0 (Pdcd1lg2 protein, mouse)
RN  - 0 (Programmed Cell Death 1 Ligand 2 Protein)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 0 (Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Antigen Presentation
MH  - Antigens, CD
MH  - *Antigens, Surface
MH  - Apoptosis Regulatory Proteins
MH  - B7-1 Antigen/*immunology
MH  - CD28 Antigens/metabolism
MH  - Dendritic Cells/*immunology
MH  - Gene Library
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Programmed Cell Death 1 Ligand 2 Protein
MH  - Programmed Cell Death 1 Receptor
MH  - Protein Binding
MH  - Proteins/metabolism
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/*immunology
PMC - PMC2193370
EDAT- 2001/04/03 10:00
MHDA- 2001/05/22 10:01
PMCR- 2001/10/02
CRDT- 2001/04/03 10:00
PHST- 2001/04/03 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/04/03 10:00 [entrez]
PHST- 2001/10/02 00:00 [pmc-release]
AID - 010159 [pii]
AID - 10.1084/jem.193.7.839 [doi]
PST - ppublish
SO  - J Exp Med. 2001 Apr 2;193(7):839-46. doi: 10.1084/jem.193.7.839.