PMID- 11284324
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20190822
IS  - 0003-2654 (Print)
IS  - 0003-2654 (Linking)
VI  - 126
IP  - 3
DP  - 2001 Mar
TI  - Carbon paste-based electrochemical detectors for microchip capillary 
      electrophoresis/electrochemistry.
PG  - 277-80
AB  - The first reported use of a carbon paste electrochemical detector for microchip 
      capillary electrophoresis (CE) is described. Poly(dimethylsiloxane) (PDMS)-based 
      microchip CE devices were constructed by reversibly sealing a PDMS layer 
      containing separation and injection channels to a separate PDMS layer that 
      contained carbon paste working electrodes. End-channel amperometric detection 
      with a single electrode was used to detect amino acids derivatized with 
      naphthalene dicarboxaldehyde. Two electrodes were placed in series for dual 
      electrode detection. This approach was demonstrated for the detection of 
      copper(II) peptide complexes. A major advantage of carbon paste is that catalysts 
      can be easily incorporated into the electrode. Carbon paste that was chemically 
      modified with cobalt phthalocyanine was used for the detection of thiols 
      following a CE separation. These devices illustrate the potential for an easily 
      constructed microchip CE system with a carbon-based detector that exhibits 
      adjustable selectivity.
FAU - Martin, R S
AU  - Martin RS
AD  - Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant 
      Avenue, Lawrence, Kansas 66047, USA. slunte@ukans.edu
FAU - Gawron, A J
AU  - Gawron AJ
FAU - Fogarty, B A
AU  - Fogarty BA
FAU - Regan, F B
AU  - Regan FB
FAU - Dempsey, E
AU  - Dempsey E
FAU - Lunte, S M
AU  - Lunte SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Sulfhydryl Compounds)
RN  - 7440-44-0 (Carbon)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Carbon
MH  - Copper/analysis
MH  - Electrodes
MH  - Electrophoresis, Capillary/*instrumentation
MH  - Microchemistry/instrumentation
MH  - Sulfhydryl Compounds/analysis
EDAT- 2001/04/04 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/04/04 10:00
PHST- 2001/04/04 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/04/04 10:00 [entrez]
AID - 10.1039/b009827m [doi]
PST - ppublish
SO  - Analyst. 2001 Mar;126(3):277-80. doi: 10.1039/b009827m.