PMID- 11285567
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20190831
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 64
IP  - 1
DP  - 2001 May
TI  - Prevalence and distribution of human herpesvirus 6 variants A and B in adult 
      human brain.
PG  - 42-6
AB  - The presence of human herpesvirus 6 (HHV-6) in brain tissues of 40 consecutive 
      post-mortem cases was examined. For each case, autopsy samples were collected 
      from the cerebellum, frontal, temporal, parietal and occipital lobes of both 
      sides of the brain. HHV-6 DNA was detected by nested polymerase chain reaction 
      and characterised into variants A and B. Overall, 97/400 (24.3%) samples were 
      positive for HHV-6 DNA with 16 being variant A and 81 being variant B, but none 
      of the samples harboured both variants. When analysed by patient, 34/40 (85%) had 
      HHV-6 DNA detected in the brain. The viral DNA positivity did not show 
      significant variation with gender and age. Four patients harboured variant A, 23 
      harboured variant B, and seven had both variants at different positions. The 
      results indicate that both HHV-6A and HHV-6B are neurotropic and human brain may 
      be another site for latency. HHV-6B was detected in brain tissues of a majority 
      (75%) of the studied population and with a widespread distribution within the 
      brain. Although the observed prevalence of HHV-6A in brain is lower (27.5%), in 
      view of its lower seroprevalence, the neuroinvasive potential of variant A may be 
      comparable to that of variant B. Although both variants are potential pathogens 
      for the nervous system, the fact that they can exist, probably for most of the 
      time, as commensals in human brain needs to be considered when interpreting their 
      roles in neuropathology.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Chan, P K
AU  - Chan PK
AD  - Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales 
      Hospital, Shatin, New Territories, Hong Kong SAR, China. paulkschan@cu.hk.edu.hk
FAU - Ng, H K
AU  - Ng HK
FAU - Hui, M
AU  - Hui M
FAU - Cheng, A F
AU  - Cheng AF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*virology
MH  - Cerebellum/virology
MH  - DNA Primers
MH  - DNA, Viral/analysis/isolation & purification
MH  - Female
MH  - Frontal Lobe/virology
MH  - Herpesvirus 6, Human/classification/genetics/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occipital Lobe/virology
MH  - Parietal Lobe/virology
MH  - Polymerase Chain Reaction
MH  - Sensitivity and Specificity
MH  - Temporal Lobe/virology
EDAT- 2001/04/04 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/04/04 10:00
PHST- 2001/04/04 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/04/04 10:00 [entrez]
AID - 10.1002/jmv.1015 [pii]
AID - 10.1002/jmv.1015 [doi]
PST - ppublish
SO  - J Med Virol. 2001 May;64(1):42-6. doi: 10.1002/jmv.1015.