PMID- 11286165
OWN - NLM
STAT- MEDLINE
DCOM- 20021210
LR  - 20131121
IS  - 1002-1892 (Print)
IS  - 1002-1892 (Linking)
VI  - 15
IP  - 2
DP  - 2001 Mar
TI  - [Effect of fetal spinal cord graft with nerve growth factor and nimodipine in 
      secondary injury of spinal cord of adult rat].
PG  - 74-6
AB  - OBJECTIVE: To observe the effect of nerve growth factor (NGF) and nimodipine (NP) 
      on fetal spinal cord graft in repair of injury of spinal cord. METHODS: A total 
      of 144 adult Wistar rats were included in this study. All were made as the 
      hemi-section cavity injury model at the lumbar enlargement and divided into three 
      groups: fetal spinal cord graft (group Tr), fetal spinal cord graft with NGF 
      (group TN), and fetal spinal cord graft with NGF and NP (group TNN). The 
      intracellular concentration of free ionic calcium was measured at the 4th, 8th, 
      and 24th hour, and superoxidase (SOD) and malondialdehyde (MDA) at 3rd, 6th, 
      12th, 24th and 72nd hour after operation. RESULTS: After spinal cord was injured, 
      the concentration of MDA and intracellular concentration of free ionic calcium 
      increased and reached to the peak at the 6th and 8th hour respectively, but SOD 
      decreased and at 24th hour to its vale. The MDA was significantly lower in group 
      TN than in group Tr, while the SOD was higher (P < 0.05). There was no 
      significant difference on intracellular free ionic calcium concentration between 
      group Tr and TN. The concentration of SOD of group TNN was the highest and the 
      intracellular concentration of free ionic calcium was the lowest in the three 
      groups (P < 0.05). The weekly mortality was 33%, 31%, 17% respectively in group 
      Tr, TN and TNN. The mortality of group TNN was significantly lower than the other 
      two groups (P < 0.01). CONCLUSION: Although the fetal spinal cord graft is an 
      effective method to repair laboratory spinal cord injury, NGF and ND can 
      interrupt secondary injury and increase survival rate of the host.
FAU - Deng, S L
AU  - Deng SL
AD  - Research Institute of Surgery, Daping Hospital, Third Military Medical 
      University, Chongqing, P. R. China 400042. Dengshaoli@163.net
FAU - Yuan, T
AU  - Yuan T
FAU - Liao, W H
AU  - Liao WH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
JT  - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = 
      Chinese journal of reparative and reconstructive surgery
JID - 9425194
RN  - 0 (Calcium Channel Blockers)
RN  - 57WA9QZ5WH (Nimodipine)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Calcium Channel Blockers/*therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Fetal Tissue Transplantation
MH  - Male
MH  - Nerve Growth Factor/*therapeutic use
MH  - Nimodipine/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Spinal Cord/embryology/*transplantation
MH  - Spinal Cord Injuries/*therapy
EDAT- 2001/04/05 10:00
MHDA- 2002/12/11 04:00
CRDT- 2001/04/05 10:00
PHST- 2001/04/05 10:00 [pubmed]
PHST- 2002/12/11 04:00 [medline]
PHST- 2001/04/05 10:00 [entrez]
PST - ppublish
SO  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2001 Mar;15(2):74-6.