PMID- 11287022
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 75
IP  - 4
DP  - 2001 Apr
TI  - Serum human chorionic gonadotropin levels are correlated with body mass index 
      rather than route of administration in women undergoing in vitro 
      fertilization--embryo transfer using human menopausal gonadotropin and 
      intracytoplasmic sperm injection.
PG  - 700-4
AB  - OBJECTIVE: To compare subcutaneous (SC) and intramuscular (IM) hCG administration 
      and their association with body mass index (BMI) in women undergoing IVF-ET using 
      hMG and ICSI. DESIGN: Prospective, randomized controlled trial. SETTING: Private 
      infertility clinic. PATIENT(S): Twenty-one ovulatory women, 29-39 years, were 
      enrolled. Treatment of one patient who failed to respond to hMG was canceled. 
      INTERVENTION(S): A standard IVF-ET treatment plan using an initial dose of 300 U 
      of hMG was followed. Patients were randomly assigned to receive 10,000 IU hCG, 
      either IM in the gluteal region or SC in the lower abdomen. Exactly 12 hours 
      later, serum for hCG determination was obtained. All oocytes were fertilized 
      using ICSI technology. MAIN OUTCOME MEASURE(S): Human chorionic gonadotropin 
      levels 12 hours after injection, BMI, and oocyte maturity. RESULT(S): No 
      significant differences in hCG levels were found, with mean levels of 225 +/- 24 
      mIU/mL for SC injection versus 213 +/- 26 mIU/mL for IM injection. No differences 
      were observed in the percentage of mature oocytes. A significant negative 
      correlation was found between BMI and hCG levels in all patients, regardless of 
      route of administration. CONCLUSION(S): The highest levels of hCG were measured 
      in women with the lowest BMI. Patients' body size, rather than route of hCG 
      delivery, appears to determine circulating levels of hCG.
FAU - Elkind-Hirsch, K E
AU  - Elkind-Hirsch KE
AD  - Center for Reproduction at Gramercy, MacGregor Medical Association, Texas, 
      Houston, USA. res-keh@womans.com
FAU - Bello, S
AU  - Bello S
FAU - Esparcia, L
AU  - Esparcia L
FAU - Phillips, K
AU  - Phillips K
FAU - Sheiko, A
AU  - Sheiko A
FAU - McNichol, M
AU  - McNichol M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Chorionic Gonadotropin)
RN  - 4TI98Z838E (Estradiol)
RN  - 61489-71-2 (Menotropins)
SB  - IM
MH  - Adult
MH  - *Body Mass Index
MH  - Chorionic Gonadotropin/*administration & dosage/*blood/therapeutic use
MH  - *Embryo Transfer
MH  - Estradiol/blood
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Injections, Intramuscular
MH  - Injections, Subcutaneous
MH  - Menotropins/*therapeutic use
MH  - Menstrual Cycle
MH  - Oocytes/cytology
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Sperm Injections, Intracytoplasmic
EDAT- 2001/04/05 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/04/05 10:00
PHST- 2001/04/05 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/04/05 10:00 [entrez]
AID - S0015-0282(00)01790-8 [pii]
AID - 10.1016/s0015-0282(00)01790-8 [doi]
PST - ppublish
SO  - Fertil Steril. 2001 Apr;75(4):700-4. doi: 10.1016/s0015-0282(00)01790-8.