PMID- 11287064
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190831
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 127
IP  - 1
DP  - 2001 Mar 29
TI  - Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of 
      prairie and montane voles.
PG  - 51-61
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in normal brain 
      development. In the present study, we examined the ontogenetic pattern of BDNF 
      gene expression in both monogamous prairie voles (Microtus ochrogaster) and 
      promiscuous montane voles (M. montanus); two closely related microtine rodents 
      that differ in life strategy and social behavior. In both species, BDNF mRNA 
      showed an early appearance and a transient expression in a regionally specific 
      manner. In the dentate gyrus and CA3 region of the hippocampus, BDNF mRNA was 
      found neonatally, increased gradually during development, and reached a peak at 
      weaning, followed by a subsequent decline to the adult level. In the 
      paraventricular nucleus of the hypothalamus, levels of BDNF mRNA persisted until 
      weaning, followed by a significant increase to the adult levels at 3 months of 
      age. BDNF mRNA also demonstrated a species-specific developmental pattern. In the 
      cingulate cortex, BDNF mRNA labeling displayed a transient increase in the second 
      and third postnatal weeks followed by a subsequent decrease to the adult level in 
      prairie voles, but persisted throughout the course of development in montane 
      voles. In general, montane voles achieved an adult pattern of BDNF mRNA 
      expression earlier than did prairie voles. Together, these data indicate that 
      BDNF may function differently in infant and adult brains, and that the two 
      species of voles differ in the ontogenetic pattern of BDNF mRNA expression in a 
      regional-specific manner, which may be associated with their different life 
      strategy and brain and behavioral development.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Psychology and Program of Neuroscience, Florida State University, 
      Tallahassee FL 32306, USA.
FAU - Fowler, C D
AU  - Fowler CD
FAU - Wang, Z
AU  - Wang Z
LA  - eng
GR  - MHR01-58616/MH/NIMH NIH HHS/United States
GR  - MHR29-54554/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Arvicolinae/*physiology
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Male
MH  - Prosencephalon/*growth & development/*physiology
MH  - RNA, Messenger/analysis
MH  - Social Behavior
MH  - Species Specificity
EDAT- 2001/04/05 10:00
MHDA- 2001/07/19 10:01
CRDT- 2001/04/05 10:00
PHST- 2001/04/05 10:00 [pubmed]
PHST- 2001/07/19 10:01 [medline]
PHST- 2001/04/05 10:00 [entrez]
AID - S0165380601001110 [pii]
AID - 10.1016/s0165-3806(01)00111-0 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2001 Mar 29;127(1):51-61. doi: 
      10.1016/s0165-3806(01)00111-0.