PMID- 11287790
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20171101
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 43
IP  - 3
DP  - 2001
TI  - Polymorphism of the 5'-upstream region of the human SNAP-25 gene: an association 
      analysis with schizophrenia.
PG  - 131-3
AB  - Recent studies have suggested that synaptic abnormalities may be part of the 
      pathophysiology of schizophrenia. SNAP-25 (synaptosomal-associated protein of 25 
      kD) is one of the synaptic proteins responsible for presynaptic 
      neurotransmission, axonal elongation and synaptogenesis. Genetic variation in the 
      5'-upstream region of the SNAP-25 gene was analyzed in 87 unrelated schizophrenic 
      patients and 100 healthy controls. A novel polymorphic (TAAA)(n) tandem repeat 
      was identified in the 5'-upstream region. There were no significant differences 
      between the patient and the control groups in the distribution of repeat numbers 
      of alleles or genotypes. In addition, no associations were found between the 
      polymorphism for subtypes, longitudinal courses or positive family history of the 
      patients. Our results suggest that polymorphisms in the 5'-upstream region of the 
      SNAP-25 gene have no association with schizophrenia.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Tachikawa, H
AU  - Tachikawa H
AD  - Department of Psychiatry, Kurita Hospital, Ibaraki, Japan. mg8@ea.mbn.or.jp
FAU - Harada, S
AU  - Harada S
FAU - Kawanishi, Y
AU  - Kawanishi Y
FAU - Okubo, T
AU  - Okubo T
FAU - Suzuki, T
AU  - Suzuki T
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (SNAP25 protein, human)
RN  - 0 (Synaptosomal-Associated Protein 25)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Membrane Proteins
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*genetics
MH  - *Polymorphism, Genetic
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Schizophrenia/*genetics/pathology
MH  - Synaptosomal-Associated Protein 25
MH  - Tandem Repeat Sequences
EDAT- 2001/04/05 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/04/05 10:00
PHST- 2001/04/05 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/04/05 10:00 [entrez]
AID - 54880 [pii]
AID - 10.1159/000054880 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2001;43(3):131-3. doi: 10.1159/000054880.