PMID- 11287814
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20191210
IS  - 0031-7012 (Print)
IS  - 0031-7012 (Linking)
VI  - 62
IP  - 3
DP  - 2001
TI  - Reinforcing effects of MDMA ("ecstasy") in drug-naive and cocaine-trained rats.
PG  - 138-44
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is one of the most prevalent 
      illegal drugs of abuse among European adolescents, a population not generally 
      experienced with respect to "hard" drugs such as cocaine. We, therefore, 
      determined the reinforcing effect of intravenously self-administered MDMA in a 
      fixed ratio 1 time-out 150 s schedule of reinforcement in rats that were truly 
      drug naive and compared it to cocaine-trained rats. The reinforcing effect of 
      MDMA [0.032-10 mg/(kg.injection)] did not differ between drug-naive rats and 
      cocaine-trained ones. MDMA sensitized the animals to its own rate-increasing 
      effect but not to that of cocaine. When MDMA was tested after cocaine, there was 
      no carryover of cocaine's reinforcing effect to that of MDMA, suggesting that 
      MDMA and cocaine produce distinct interoceptive stimuli in rats.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Ratzenboeck, E
AU  - Ratzenboeck E
AD  - Division of Neurochemistry, Department of Psychiatry, University of Innsbruck, 
      Anichstrasse 35, A-6020 Innsbruck, Austria.
FAU - Saria, A
AU  - Saria A
FAU - Kriechbaum, N
AU  - Kriechbaum N
FAU - Zernig, G
AU  - Zernig G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Hallucinogens)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Conditioning, Operant
MH  - Dopamine Uptake Inhibitors/administration & dosage/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - *Reinforcement, Psychology
EDAT- 2001/04/05 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/04/05 10:00
PHST- 2001/04/05 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/04/05 10:00 [entrez]
AID - 56086 [pii]
AID - 10.1159/000056086 [doi]
PST - ppublish
SO  - Pharmacology. 2001;62(3):138-44. doi: 10.1159/000056086.