PMID- 11288966
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20200225
IS  - 0160-9289 (Print)
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 24
IP  - 3
DP  - 2001 Mar
TI  - Clinical characteristics of patients with increased urinary excretion of 
      adrenaline in mild to moderate heart failure.
PG  - 209-13
AB  - BACKGROUND: We have previously demonstrated that adrenaline (AD) is released into 
      the circulation during acute myocardial infarction and is associated with a more 
      severe clinical course. The role of elevated AD levels in congestive heart 
      failure is not known. HYPOTHESIS: The study aimed to determine whether increased 
      daily AD excretion is associated with more severe clinical symptoms and a more 
      complicated clinical course in patients with exacerbation of congestive heart 
      failure (CHF). METHODS: Urinary excretion of AD, noradrenaline, magnesium (Mg), 
      and potassium (K), serum levels of aldosterone, K, and Mg, as well as the 
      incidence of arrhythmias (24-h Holter) were assessed in 49 patients with CHF New 
      York Heart Association (NYHA) class II-III. The patients were allocated to two 
      groups, with normal (Group 1) and increased (Group 2) excretion of AD. RESULTS: 
      Groups 1 and 2 did not differ in respect of age, etiology of CHF, or the 
      medication used. Also, left ventricular ejection fraction was similar in the two 
      groups. However, left ventricular end-diastolic dimension was greater in Group 2 
      (61+/-9 vs. 55+/-11 mm, p<0.05), as was the proportion of patients in NYHA class 
      III (74 vs. 40%). Group 2 was also characterized by increased urinary excretion 
      of Mg (60+/-24 vs. 43+/-16 mg/24 h, p < 0.007) and the presence of more complex 
      and numerous ventricular arrhythmias (74 vs. 37% and 68 vs. 33% of patients, 
      respectively). CONCLUSIONS: Urinary excretion of AD is increased only in a 
      subgroup of patients with CHF. These patients are characterized by a more 
      advanced NYHA class, increased end-diastolic left ventricular diameter, and 
      increased urinary excretion of magnesium. It is likely that all these factors 
      contribute to the presence of more complex and numerous ventricular arrhythmias 
      in this subgroup of patients.
FAU - Grochowicz, U
AU  - Grochowicz U
AD  - Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, 
      Warsaw, Poland.
FAU - Wolk, R
AU  - Wolk R
FAU - Bednarz, B
AU  - Bednarz B
FAU - Budaj, A
AU  - Budaj A
FAU - Ceremuzynski, L
AU  - Ceremuzynski L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Epinephrine/*urine
MH  - Female
MH  - Heart Failure/physiopathology/*urine
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sympathetic Nervous System/physiopathology
MH  - Ventricular Function, Left
PMC - PMC6654855
EDAT- 2001/04/06 10:00
MHDA- 2001/07/31 10:01
PMCR- 2009/02/03
CRDT- 2001/04/06 10:00
PHST- 2001/04/06 10:00 [pubmed]
PHST- 2001/07/31 10:01 [medline]
PHST- 2001/04/06 10:00 [entrez]
PHST- 2009/02/03 00:00 [pmc-release]
AID - CLC4960240307 [pii]
AID - 10.1002/clc.4960240307 [doi]
PST - ppublish
SO  - Clin Cardiol. 2001 Mar;24(3):209-13. doi: 10.1002/clc.4960240307.