PMID- 11289101
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20210102
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 61
IP  - 6
DP  - 2001 Mar 15
TI  - Protection of mice against leukemia after vaccination with bone marrow-derived 
      dendritic cells loaded with apoptotic leukemia cells.
PG  - 2386-9
AB  - Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that need 
      to be activated before they can function to initiate primary and secondary immune 
      responses in vivo. DCs are also specialized to maintain peripheral tolerance to 
      self after uptake of apoptotic material, likely corresponding to both apoptotic 
      bodies and whole apoptotic cells. Here, we report that murine bone marrow-derived 
      DCs can be activated in vitro by exogenous signals received from apoptotic 
      leukemia cells expressing on the cell surface a model tumor-associated antigen. 
      Injected in vivo, these exogenously activated DCs can function as adjuvants to 
      protect mice against leukemia by stimulating an antigen-specific 
      cellular-mediated cytotoxic immune response. To our knowledge, this is the first 
      report indicating that DCs loaded with apoptotic leukemia cells protect mice 
      against leukemia development.
FAU - Paczesny, S
AU  - Paczesny S
AD  - Laboratoire d'Histologie et de Th rapie Genique, Universite de Medecine 
      Paris-XIII, Bobigny, France.
FAU - Beranger, S
AU  - Beranger S
FAU - Salzmann, J L
AU  - Salzmann JL
FAU - Klatzmann, D
AU  - Klatzmann D
FAU - Colombo, B M
AU  - Colombo BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (CD4 Antigens)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Antigens, Neoplasm/immunology
MH  - Apoptosis/*physiology
MH  - Bone Marrow Cells/cytology/immunology
MH  - CD4 Antigens/genetics/immunology
MH  - Cancer Vaccines/*immunology
MH  - Cytotoxicity, Immunologic
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Gene Transfer Techniques
MH  - Humans
MH  - Immunotherapy, Adoptive
MH  - Leukemia L1210/genetics/*immunology/prevention & control
MH  - Mice
MH  - Mice, Inbred DBA
MH  - Phagocytosis/immunology
EDAT- 2001/04/06 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/04/06 10:00
PHST- 2001/04/06 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/04/06 10:00 [entrez]
PST - ppublish
SO  - Cancer Res. 2001 Mar 15;61(6):2386-9.