PMID- 11289700
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20131121
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 62
IP  - 7
DP  - 2001 Apr 6
TI  - Influence of propylthiouracil treatment on oxidative stress and nitric oxide in 
      Basedow disease patients.
PG  - 495-503
AB  - Oxidative stress parameters and nitric oxide (NO) values were determined in 27 
      newly diagnosed Basedow patients before and after 1 mo of propylthiouracil (PTU) 
      therapy and in 15 healthy controls. Basedow patients exhibited increased 
      triiodothyronine (T3) and thyroxine (T4) and decreased thyroid-stimulating 
      hormone (TSH) values compared to controls. Significantly higher thiobarbituric 
      acid-reactive substances (TBARS), NO and glutathione (GSH) levels, and CuZn 
      superoxide dismutase (CuZn SOD) activity were found in Basedow patients in 
      comparison to controls, regardless of sex. Treatment with PTU (3 x 100 mg/d for 
      30 d) was effective in decreasing T1 and T4 and increasing TSH levels. 
      Significantly decreased NO and TBARS and increased GSH and CuZn SOD levels were 
      observed in PTU-treated Basedow patients compared to pre-PTU administration. 
      PTU-treated patients compared to controls still exhibited significantly higher T3 
      and lower TSH values and higher NO, TBARS, GSH, and CuZn SOD levels. The induced 
      antioxidant defense and decrease in NO) values in response to PTU therapy 
      emphasizes the role of PTU as an antithyroid drug, where the ability to diminish 
      hyperthyroidism results in decreased catabolism and lower oxidant generation.
FAU - Seven, R
AU  - Seven R
AD  - Department of General Surgery, Istanbul Medical Faculty, Istanbul University, 
      Turkey. bbseven@superonline.com.tr
FAU - Gelisgen, R
AU  - Gelisgen R
FAU - Seven, A
AU  - Seven A
FAU - Erbil, Y
AU  - Erbil Y
FAU - Bozbora, A
AU  - Bozbora A
FAU - Burcak, G
AU  - Burcak G
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Antithyroid Agents)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 721M9407IY (Propylthiouracil)
RN  - 9002-71-5 (Thyrotropin)
RN  - GAN16C9B8O (Glutathione)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Antithyroid Agents/*therapeutic use
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Glutathione/blood
MH  - Graves Disease/*drug therapy/metabolism/*physiopathology
MH  - Humans
MH  - Male
MH  - Nitric Oxide/*metabolism
MH  - Oxidative Stress/*drug effects
MH  - Propylthiouracil/*therapeutic use
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 2001/04/06 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/04/06 10:00
PHST- 2001/04/06 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/04/06 10:00 [entrez]
AID - 10.1080/152873901300007806 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2001 Apr 6;62(7):495-503. doi: 
      10.1080/152873901300007806.