PMID- 11291059
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 92
IP  - 2
DP  - 2001 Apr 15
TI  - Study of human leukocyte antigen class I phenotypes in Moroccan patients with 
      nasopharyngeal carcinoma.
PG  - 294-7
AB  - Previous reports demonstrated an association between the human leukocyte antigen 
      (HLA) and risk for nasopharyngeal carcinoma (NPC) among the Chinese in Singapore, 
      a population with a high incidence of this malignancy. In our study, we assess 
      the association between HLA and NPC in Morocco, a median-prevalence area for this 
      cancer, where NPC presents the particularity of also affecting young individuals. 
      Using the standard microlympho-cytotoxicity test, we typed a total of 154 
      Moroccan NPC patients and 257 unrelated healthy controls for their HLA-A and B 
      antigens. The results of these analyses show that the frequencies of HLA-A10, 
      HLA-B13 and HLA-B18 were found to be higher in the NPC group than in the control 
      group, whereas HLA-A9 was associated with a decreased risk. After correction for 
      the number of specificities tested, these differences were statistically 
      significant only for HLA-B18 (corrected p value [pc] < 0.023, relative risk [RR] 
      = 4.14) and HLA-A9 (pc < 0.023, RR = 0.45). The comparison of the distribution of 
      the HLA antigens in younger and older cohorts of patients shows that the 
      incidence of HLA-A10 and HLA- B18 was higher in the older group, whereas the 
      frequencies of HLA-A19 and HLA-B13 were significantly higher in younger patients 
      compared with controls. The presence of both HLA-A19 and HLA-B13 phenotypes 
      correlated with an increased risk of developing NPC among overall patients 
      compared with controls. According to the sex distribution, increased frequency of 
      HLA-B18 was found in male and female NPC patients compared with controls, whereas 
      the frequency of HLA-A10 was higher only in male NPC patients compared with 
      controls.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Dardari, R
AU  - Dardari R
AD  - Institut Pasteur du Maroc, 1 Rue Abou Kacem Ez-Zahraoui, B.P. 120-Casablanca, 
      Morocco.
FAU - Khyatti, M
AU  - Khyatti M
FAU - Jouhadi, H
AU  - Jouhadi H
FAU - Benider, A
AU  - Benider A
FAU - Ettayebi, H
AU  - Ettayebi H
FAU - Kahlain, A
AU  - Kahlain A
FAU - Mansouri, A
AU  - Mansouri A
FAU - El Gueddari, B
AU  - El Gueddari B
FAU - Benslimane, A
AU  - Benslimane A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Carcinoma/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - Nasopharyngeal Neoplasms/epidemiology/*genetics
MH  - Phenotype
MH  - Sex Factors
EDAT- 2001/04/06 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/04/06 10:00
PHST- 2001/04/06 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/04/06 10:00 [entrez]
AID - 10.1002/1097-0215(200102)9999:9999<::AID-IJC1177>3.0.CO;2-9 [pii]
AID - 10.1002/1097-0215(200102)9999:9999<::aid-ijc1177>3.0.co;2-9 [doi]
PST - ppublish
SO  - Int J Cancer. 2001 Apr 15;92(2):294-7. doi: 
      10.1002/1097-0215(200102)9999:9999<::aid-ijc1177>3.0.co;2-9.