PMID- 11293323
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20161124
IS  - 0190-2148 (Print)
IS  - 0190-2148 (Linking)
VI  - 27
IP  - 3
DP  - 2001 Apr-May
TI  - Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus.
PG  - 185-96
AB  - Search for quantitative trait loci (QTLs) has been successful in the past decade 
      by revealing numerous susceptibility to lung cancer loci in specially designed 
      experimental crosses in mice. Although qualitative aspects of lung tumorigenesis 
      are also genetically controlled, no loci affecting such traits have so far been 
      identified. We analyzed a series of lung tumors derived from various inbred and 
      recombinant congenic strains and F2 crosses for two histological characteristics: 
      nuclear cytoplasmic invaginations (NCIs) and lymphocytic infiltration (LI) and 
      performed linkage analysis. A significant linkage of the Kras-2 locus with 
      presence or absence of NCI was detected. The implications of this linkage as well 
      as the relationships between NCI, LI, tumor size and Kras-2 alleles are 
      discussed.
FAU - Tripodis, N
AU  - Tripodis N
AD  - The Netherlands Cancer Institute, Division of Molecular Genetics, Amsterdam, The 
      Netherlands.
FAU - Demant, P
AU  - Demant P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Carcinogens)
RN  - 0 (KRAS protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
RN  - EC 3.6.5.2 (ras Proteins)
RN  - P8M1T4190R (Ethylnitrosourea)
SB  - IM
MH  - Animals
MH  - Carcinogens/toxicity
MH  - Cell Nucleus/*pathology
MH  - Ethylnitrosourea/toxicity
MH  - Female
MH  - Genetic Linkage
MH  - Lung Neoplasms/chemically induced/*genetics/*pathology
MH  - Lymphocytes, Tumor-Infiltrating/pathology
MH  - Mice
MH  - Mice, Congenic
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins p21(ras)
MH  - ras Proteins
EDAT- 2001/04/11 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/04/11 10:00
PHST- 2001/04/11 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/04/11 10:00 [entrez]
PST - ppublish
SO  - Exp Lung Res. 2001 Apr-May;27(3):185-96.