PMID- 11295229
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 88
IP  - 1-2
DP  - 2001 Mar 31
TI  - Memory consolidation in day-old chicks requires BDNF but not NGF or NT-3; an 
      antisense study.
PG  - 26-36
AB  - Neurotrophins have been implicated in memory consolidation and recall as well as 
      in other forms of neural plasticity. This study examined the effects of 
      Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF) and 
      Neurotrophin-3 (NT-3) on consolidation of memory for a one-trial passive 
      avoidance task in day-old chicks. In this task chicks, having pecked once at a 
      bitter tasting bead, avoid a similar but dry bead subsequently. Intracerebral 
      administration of antisense ODNs to BDNF 6-12 h prior to training induced amnesia 
      for the avoidance response by 3 h after training. Administration of a "control" 
      scrambled sequence or saline had no effect on recall; chicks continued to avoid 
      the bead. Treatment with BDNF-AS did not inhibit shorter-term recall; amnesia was 
      not present 1 h after training, but prevented longer-term recall, as amnesia was 
      still present 24 h after training. Treatment with BDNF-antisense reduced both 
      BDNF mRNA and BDNF protein in the chick brain, but did not alter mRNA levels of 
      glyceraldehyde-3-phosphate dehydrogenase. By contrast, no effect of antisense to 
      NGF or NT-3 on behaviour was observed, even though administration reduced the 
      mRNA for each. There were no significant effects of any antisense on other 
      behavioural measures at the doses used. Thus we conclude that BDNF has a specific 
      role in memory consolidation for the passive avoidance task.
FAU - Johnston, A N
AU  - Johnston AN
AD  - Brain and Behaviour Research Group, Department of Biological Sciences, The Open 
      University, Milton Keynes MK7 6AA, UK. a.n.b.johnston@open.ac.uk
FAU - Rose, S P
AU  - Rose SP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Avoidance Learning/*physiology
MH  - Brain Chemistry/physiology
MH  - Brain-Derived Neurotrophic Factor/analysis/genetics
MH  - Chickens
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Feeding Behavior/physiology
MH  - In Situ Hybridization
MH  - Memory/*physiology
MH  - Nerve Growth Factor/genetics
MH  - Nerve Growth Factors/*genetics
MH  - Neurotrophin 3/genetics
MH  - Oligonucleotides, Antisense/pharmacology
MH  - RNA, Messenger/analysis
EDAT- 2001/04/11 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/04/11 10:00
PHST- 2001/04/11 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/04/11 10:00 [entrez]
AID - S0169328X0100016X [pii]
AID - 10.1016/s0169-328x(01)00016-x [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):26-36. doi: 
      10.1016/s0169-328x(01)00016-x.