PMID- 11295574
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20191025
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 12
IP  - 4
DP  - 2001 May-Jun
TI  - Multiple endocrine neoplasia type 1: new clinical and basic findings.
PG  - 173-8
AB  - Multiple endocrine neoplasia type 1 (MEN1) provides a prime example of how a rare 
      disease can advance our understanding of basic cell biology, neoplasia and common 
      endocrine tumors. MEN1 is expressed mainly as parathyroid, enteropancreatic 
      neuroendocrine, anterior pituitary and foregut carcinoid tumors. It is an 
      autosomal dominant disease caused by mutation of the MEN1 gene. Since its 
      identification, the MEN1 gene has been implicated in many common endocrine and 
      non-endocrine tumors. This is a brief overview of recent scientific advances 
      relating to MEN1, including newly recognized clinical features that are now 
      better characterized by genetic analysis, insights into the function of the 
      MEN1-encoded protein menin, and refined recommendations for mutation testing and 
      tumor screening, which highlight our increasing understanding of this complex 
      syndrome.
FAU - Schussheim, D H
AU  - Schussheim DH
AD  - Metabolic Diseases Branch, NIDDK, NIH, 20892, Bethesda, MD 20892, USA. 
      dh208@columbia.edu
FAU - Skarulis, M C
AU  - Skarulis MC
FAU - Agarwal, S K
AU  - Agarwal SK
FAU - Simonds, W F
AU  - Simonds WF
FAU - Burns, A L
AU  - Burns AL
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Marx, S J
AU  - Marx SJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adrenal Cortex Neoplasms/genetics
MH  - Angiofibroma/genetics
MH  - Humans
MH  - Leiomyoma/genetics
MH  - *Multiple Endocrine Neoplasia Type 1/genetics
MH  - Mutation
MH  - Neoplasm Proteins/genetics/physiology
MH  - Pheochromocytoma/genetics
MH  - *Proto-Oncogene Proteins
MH  - Skin Neoplasms/genetics
MH  - Thyroid Neoplasms/genetics
RF  - 69
EDAT- 2001/04/11 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/04/11 10:00
PHST- 2001/04/11 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/04/11 10:00 [entrez]
AID - S1043-2760(00)00372-6 [pii]
AID - 10.1016/s1043-2760(00)00372-6 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2001 May-Jun;12(4):173-8. doi: 
      10.1016/s1043-2760(00)00372-6.