PMID- 11296153
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20190513
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 153
IP  - 8
DP  - 2001 Apr 15
TI  - Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study 
      conducted in Santiago, Chile.
PG  - 794-8
AB  - The human leukocyte antigen (HLA) system plays a crucial role in the autoimmune 
      process leading to childhood diabetes. The purpose of this study was to evaluate 
      the association between type 1 diabetes and the polymorphism encoded by the 
      HLA-DQB1 gene by using case-parents trios. The study area was the metropolitan 
      region of Santiago, Chile, and cases were ascertained from March 1997 to August 
      1998. Genotyping was performed in 94 trios comprising incident cases less than 17 
      years of age at the time of diagnosis and their parents. The 
      transmission/disequilibrium test was used to detect differential transmission in 
      the HLA-DQB1 locus. The authors found that alleles DQB1(*)0302 and DQB1(*)0201 
      were strongly associated with the disease. By using 1:3 matched sets of 
      cases-pseudosibs and conditional logistic regression models, allelic relative 
      risks were estimated for DQB1(*)0302 (r = 7.2, 95% confidence interval: 2.8, 
      18.5) and DQB1(*)0201 (r = 4.7, 95% confidence interval: 1.9, 11.6); DQB1(*)0301 
      was considered the baseline allele. When case-parents trios were used, alleles 
      DQB1(*)0302 and DQB1(*)0201 were strongly associated with a higher risk of type 1 
      diabetes in the population of SANTIAGO:
FAU - Santos, J L
AU  - Santos JL
AD  - Department of Epidemiology, Institute of Nutrition and Food Technology (INTA), 
      University of Chile, Santiago, Chile. jsantos@uec.inta.uchile.cl
FAU - Perez-Bravo, F
AU  - Perez-Bravo F
FAU - Carrasco, E
AU  - Carrasco E
FAU - Calvillan, M
AU  - Calvillan M
FAU - Albala, C
AU  - Albala C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Chile/epidemiology
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics
MH  - Female
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Male
MH  - Pedigree
MH  - *Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2001/04/11 10:00
MHDA- 2001/05/05 10:01
CRDT- 2001/04/11 10:00
PHST- 2001/04/11 10:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/04/11 10:00 [entrez]
AID - 10.1093/aje/153.8.794 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2001 Apr 15;153(8):794-8. doi: 10.1093/aje/153.8.794.