PMID- 11297154
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20041117
IS  - 0041-4301 (Print)
IS  - 0041-4301 (Linking)
VI  - 43
IP  - 1
DP  - 2001 Jan-Mar
TI  - HLAs in children with minimal change disease and other types of nephrotic 
      syndrome in the southern part of Turkey.
PG  - 24-8
AB  - The aim of this study was to investigate the human leukocyte antigen (HLA) 
      profile of children with nephrotic syndrome in the southern part of Turkey. 
      Seventy-eight children with nephrotic syndrome were studied for the frequency of 
      class I and class II human leukocyte antigens. Forty-seven of them were steroid 
      sensitive nephrotic syndrome (minimal change disease-MCD) and 31 were other types 
      of nephrotic syndrome. The results were compared with 133 healthy subjects for 
      HLA groups. HLA B13, Cw5, Cw7, DR4, DR7, DRw10, Drw15(2) and DQ2 in the MCD group 
      and HLA A31, B8, B13, B17, Cw2, Cw6, Cw7, DRw10 and DRw12 in the non-MCD group 
      were found significantly increased when compared to healthy controls. MCD 
      patients with frequent relapses had higher frequencies of both Cw6 and DR1 (p < 
      0.005) and MCD patients with infrequent relapses had a higher frequency of Cw7 (p 
      < 0.05). In conclusion, HLA groups may help in the early diagnosis of these 
      variants.
FAU - Karabay-Bayazit, A
AU  - Karabay-Bayazit A
AD  - Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey.
FAU - Noyan, A
AU  - Noyan A
FAU - Bayazit, Y
AU  - Bayazit Y
FAU - Ozel, A
AU  - Ozel A
FAU - Anarat, A
AU  - Anarat A
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk J Pediatr
JT  - The Turkish journal of pediatrics
JID - 0417505
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Child
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Nephrotic Syndrome/*immunology
MH  - Turkey/epidemiology
EDAT- 2001/04/12 10:00
MHDA- 2001/05/05 10:01
CRDT- 2001/04/12 10:00
PHST- 2001/04/12 10:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/04/12 10:00 [entrez]
PST - ppublish
SO  - Turk J Pediatr. 2001 Jan-Mar;43(1):24-8.