PMID- 11297278
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20200314
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 80
IP  - 4
DP  - 2001 Apr
TI  - Cecal volatile fatty acids and broiler chick susceptibility to Salmonella 
      typhimurium colonization as affected by aflatoxins and T-2 toxin.
PG  - 411-7
AB  - Four experiments were conducted using day-of-hatch, mixed-sex broiler chicks to 
      evaluate the effects of aflatoxins and T-2 toxin on cecal volatile fatty acids 
      (VFA) and the susceptibility to Salmonella colonization. All chicks in these 
      experiments were challenged orally with 10(4) cfu of Salmonella typhimurium (ST) 
      on Day 3. In Experiments 1 and 2, chicks were fed diets containing 0, 2.5, or 7.5 
      mg aflatoxins/kg of diet and were allowed to develop their microflora naturally. 
      In Experiment 3, all chicks were orally gavaged on the day of hatch with a 
      competitive exclusion (CE) culture (PREEMPT) and were fed diets containing 0, 
      2.5, or 7.5 mg T-2 toxin/kg. In Experiment 4, the chicks were fed diets 
      containing 0, 7.5, or 15.0 mg T-2 toxin/kg and one-half of the chicks were orally 
      gavaged on the day of hatch with the CE culture. In Experiments 1 and 2, with the 
      exception of increased total VFA at 5 d in chicks fed the 7.5 mg T-2 
      aflatoxins/kg diet, there were no treatment effects on cecal propionic acid, 
      total VFA, or incidence or severity of ST colonization. In Experiment 3, the only 
      alteration in concentration of cecal propionic acid or total VFA was a 
      significant reduction in total VFA at 5 d in chicks fed the 2.5 mg T-2 toxin/kg 
      diet. No significant treatment differences were observed for numbers of 
      Salmonella cecal culture-positive chicks or for numbers of ST in the cecal 
      contents. In Experiment 4, with minor exceptions, the chicks treated with the CE 
      culture had higher cecal concentrations of propionic acid and were less 
      susceptible to Salmonella colonization than the non-CE-treated chicks. In the 
      non-CE-treated chicks, T-2 toxin had no effect on any of the parameters, and 85 
      to 90% of the chicks were Salmonella cecal culture-positive. In the CE-treated 
      chicks, there was a decrease in propionic acid concentration at 3 and 11 d and an 
      increase in susceptibility to Salmonella colonization of the chicks fed the 15.0 
      mg T-2 toxin/kg diet. These results indicate that cecal concentrations of VFA can 
      be affected by toxins, such as high concentrations of T-2 toxin, and that 
      resistance to Salmonella colonization may be reduced. Further research is 
      necessary to determine the biological significance of these changes.
FAU - Kubena, L F
AU  - Kubena LF
AD  - USDA, Agricultural Research Service, Southern Plains Agricultural Research Center 
      Food and Feed Safety Research Unit, College Station, Texas 77845, USA. 
      kubena@usda.tamu.edu
FAU - Bailey, R H
AU  - Bailey RH
FAU - Byrd, J A
AU  - Byrd JA
FAU - Young, C R
AU  - Young CR
FAU - Corrier, D E
AU  - Corrier DE
FAU - Stanker, L H
AU  - Stanker LH
FAU - Rottinghaust, G E
AU  - Rottinghaust GE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - 0 (Aflatoxins)
RN  - 0 (Fatty Acids, Volatile)
RN  - I3FL5NM3MO (T-2 Toxin)
SB  - IM
MH  - Aflatoxins/*administration & dosage
MH  - Animals
MH  - Cecum/*microbiology
MH  - Chickens
MH  - Disease Susceptibility/veterinary
MH  - Fatty Acids, Volatile/*analysis
MH  - Female
MH  - Male
MH  - Poultry Diseases/microbiology
MH  - Salmonella Infections, Animal/prevention & control
MH  - Salmonella typhimurium/drug effects/*growth & development
MH  - T-2 Toxin/*administration & dosage
EDAT- 2001/04/12 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/04/12 10:00
PHST- 2001/04/12 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/04/12 10:00 [entrez]
AID - S0032-5791(19)41105-X [pii]
AID - 10.1093/ps/80.4.411 [doi]
PST - ppublish
SO  - Poult Sci. 2001 Apr;80(4):411-7. doi: 10.1093/ps/80.4.411.