PMID- 11303147
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20191104
IS  - 1065-6251 (Print)
IS  - 1065-6251 (Linking)
VI  - 8
IP  - 3
DP  - 2001 May
TI  - Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of 
      dendritic cells.
PG  - 149-54
AB  - Dendritic cells (DCs) are hematopoietic cells that initiate immune responses by 
      presenting antigen to T cells. Granulocyte-macrophage colony-stimulating factor 
      (GM-CSF) is a primary growth factor for DCs in vitro, but recently it was 
      recognized that other factors including flt3 ligand (FL) and G-CSF expand various 
      DC subsets in vivo. DCs undergo a complex series of maturation and activation 
      steps after they acquire antigen and before they can activate resting T cells. In 
      addition, they must traffic to T-cell-rich areas of lymph nodes (LN) to achieve 
      this. Each of these steps is tightly regulated, and in the last year progress has 
      been made in identifying some of the key molecules involved in each of these 
      steps. This progress will further the efforts underway to develop DCs as vaccine 
      adjuvants.
FAU - McKenna, H J
AU  - McKenna HJ
AD  - Immunex Corporation, Seattle, Washington 98101, USA. mckennah@immunex.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Hematol
JT  - Current opinion in hematology
JID - 9430802
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Hematopoietic Cell Growth Factors)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (flt3 ligand protein)
SB  - IM
MH  - Adjuvants, Immunologic/pharmacology/physiology
MH  - Adoptive Transfer/methods
MH  - Animals
MH  - Cell Culture Techniques/methods
MH  - Dendritic Cells/*drug effects/physiology/transplantation
MH  - Hematopoiesis/drug effects
MH  - Hematopoietic Cell Growth Factors/pharmacology/*physiology
MH  - Humans
MH  - Ligands
MH  - Membrane Proteins/pharmacology/*physiology
RF  - 57
EDAT- 2001/04/17 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/04/17 10:00
PHST- 2001/04/17 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/04/17 10:00 [entrez]
AID - 10.1097/00062752-200105000-00004 [doi]
PST - ppublish
SO  - Curr Opin Hematol. 2001 May;8(3):149-54. doi: 10.1097/00062752-200105000-00004.