PMID- 11303306
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20221207
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 30
IP  - 5
DP  - 2001 Apr
TI  - Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, 
      sociodemographic, serologic, and immunogenetic determinants.
PG  - 332-46
AB  - OBJECTIVE: To determine whether ethnic factors influence the presentation, 
      serologic expression and immunogenetics of systemic sclerosis (SSc), patients 
      from 3 ethnic groups were compared for clinical features, SSc-associated 
      autoantibodies, and human leukocyte antigen (HLA) class II alleles. METHODS: 
      Fifty-four Hispanics, 28 African Americans, and 79 whites from Texas with 
      recent-onset (less than 5 years) SSc enrolled in a prospective longitudinal study 
      were assessed for sociodemographic, clinical, immunologic, immunogenetic, 
      behavioral, and psychologic parameters using validated instruments and standard 
      laboratory techniques. Serologic and immunogenetic characteristics from these 
      patients and larger retrospective SSc cohorts of the same ethnic groups also were 
      examined. RESULTS: Hispanics and African Americans in the prospective cohort were 
      more likely to have diffuse skin involvement, skin pigmentary changes, digital 
      ulcers, pulmonary hypertension (African Americans), and an overall lower 
      sociodemographic status than whites, who had more facial telangiectasia and 
      hypothyroidism. In the larger combined prospective and retrospective groups of 
      SSc patients, whites were likely to have more anticentromere antibodies (ACA) and 
      African Americans more anti-U1-ribonucleoprotein (RNP) and anti-U3-RNP 
      (fibrillarin) autoantibodies. HLA-DQB1*0301 was significantly associated with SSc 
      per se in all 3 ethnic groups; HLA-DRB1*11 correlated with the anti-topoisomerase 
      I antibody response, and HLA-DRB1*01, DRB1*04, and DQB1*0501 with ACA. 
      CONCLUSIONS: Important sociodemographic, clinical, and serologic differences 
      exist between whites, African Americans, and Hispanics, despite shared genetic 
      (HLA class II) predisposing factors. The impact of these differences on prognosis 
      remain to be determined.
FAU - Reveille, J D
AU  - Reveille JD
AD  - Department of Medicine, Divisions of Rheumatology and Clinical Immunogenetics and 
      General Medicine, The University of Texas-Houston Health Science Center, Houston, 
      TX 77030 USA. jreveill@heart.med.uth.tmc.edu
FAU - Fischbach, M
AU  - Fischbach M
FAU - McNearney, T
AU  - McNearney T
FAU - Friedman, A W
AU  - Friedman AW
FAU - Aguilar, M B
AU  - Aguilar MB
FAU - Lisse, J
AU  - Lisse J
FAU - Fritzler, M J
AU  - Fritzler MJ
FAU - Ahn, C
AU  - Ahn C
FAU - Arnett, F C
AU  - Arnett FC
CN  - GENISOS Study Group
LA  - eng
GR  - M01-RR00073/RR/NCRR NIH HHS/United States
GR  - M01-RR01346/RR/NCRR NIH HHS/United States
GR  - M01-RR02558/RR/NCRR NIH HHS/United States
GR  - P50AR44888/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Black or African American/psychology/statistics & numerical data
MH  - Aged
MH  - Autoantibodies/genetics/immunology
MH  - Female
MH  - HLA Antigens/genetics/immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Hispanic or Latino/psychology/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Scleroderma, Systemic/*ethnology/immunology/psychology
MH  - Sick Role
MH  - Socioeconomic Factors
MH  - Texas/ethnology
MH  - White People/psychology/statistics & numerical data
EDAT- 2001/04/17 10:00
MHDA- 2001/06/08 10:01
CRDT- 2001/04/17 10:00
PHST- 2001/04/17 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/04/17 10:00 [entrez]
AID - S0049-0172(01)94336-7 [pii]
AID - 10.1053/sarh.2001.20268 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2001 Apr;30(5):332-46. doi: 10.1053/sarh.2001.20268.