PMID- 11303747
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 5
DP  - 2001 Apr 17
TI  - Analysis of effects and pharmacokinetics of subcutaneously administered BDNF.
PG  - 1067-72
AB  - Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family and 
      has been shown to be a potent and effective trophic factor for motor neurons and 
      other neurons of the peripheral and central nervous. Little is known, however, 
      about the relationship between the efficacy and pharmacokinetics of s.c. 
      administered BDNF. In this study, the efficacy of BDNF on motor neuron protection 
      in sciatic or facial nerve axotomy models was examined and compared with the 
      concommitant concentrations of BDNF in plasma. Delayed treatment (started at 1 
      week after surgery) of BDNF was also shown to retard choline acetyltransferase 
      reduction in sciatic nerve axotomy models.
FAU - Kishino, A
AU  - Kishino A
AD  - Sumitomo Pharmaceuticals Research Division, Osaka, Japan.
FAU - Katayama, N
AU  - Katayama N
FAU - Ishige, Y
AU  - Ishige Y
FAU - Yamamoto, Y
AU  - Yamamoto Y
FAU - Ogo, H
AU  - Ogo H
FAU - Tatsuno, T
AU  - Tatsuno T
FAU - Mine, T
AU  - Mine T
FAU - Noguchi, H
AU  - Noguchi H
FAU - Nakayama, C
AU  - Nakayama C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Brain-Derived Neurotrophic Factor/administration & 
      dosage/*pharmacokinetics/*pharmacology
MH  - Choline O-Acetyltransferase/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Facial Nerve Injuries/drug therapy/pathology
MH  - Injections, Subcutaneous
MH  - Male
MH  - Motor Neurons/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sciatic Nerve/injuries
EDAT- 2001/04/17 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/04/17 10:00
PHST- 2001/04/17 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/04/17 10:00 [entrez]
AID - 10.1097/00001756-200104170-00040 [doi]
PST - ppublish
SO  - Neuroreport. 2001 Apr 17;12(5):1067-72. doi: 10.1097/00001756-200104170-00040.