PMID- 11304078
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20041117
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 13
IP  - 5
DP  - 2001 May
TI  - Gray matter-changes and correlates of disease severity in schizophrenia: a 
      statistical parametric mapping study.
PG  - 814-24
AB  - Voxel-based morphometry has recently been used successfully to detect gray matter 
      volume reductions in schizophrenic patients. The aim of the present study was to 
      confirm the findings on gray-matter changes and to complement these by applying 
      the methodology to CSF-differences. Also, we wanted to determine whether a 
      correlation exists between a clinically defined parameter of disease severity and 
      brain morphology in schizophrenic patients. We investigated 48 schizophrenic 
      patients and compared them with 48 strictly age- and sex-matched controls. 
      High-resolution whole-brain MR-images were segmented and analyzed using SPM99. In 
      a further analysis, the covariate effect of the global assessment of 
      functioning-score (GAF) was calculated. Main findings were (i) left-dominant 
      frontal, temporal, and insular GM-reductions and (ii) GM-increases in 
      schizophrenic patients in the right basal ganglia and bilaterally in the superior 
      cerebellum; (iii) CSF-space increases in patients complementary to some 
      GM-reductions; (iv) a correlation between the GAF-score and local GM-volume in 
      the left inferior frontal and inferior parietal lobe of schizophrenic patients. 
      This study confirms and extends some earlier findings on GM-reduction and 
      detected distinct GM-increases in schizophrenic patients. These changes were 
      corroborated by complementary CSF-increases. Most importantly, a correlation 
      could be established between two particular gray matter-regions and the overall 
      disease severity, with more severely ill patients displaying a local GM-deficit. 
      These findings may be of potentially large importance for both the future 
      interpretation and design of neuroimaging studies in schizophrenia and the 
      further elucidation of possible pathophysiological processes occurring in this 
      disease.
CI  - Copyright 2001 Academic Press.
FAU - Wilke, M
AU  - Wilke M
AD  - NMR, Suicide study group, Max Planck-Institute of Psychiatry, Kraepelinstrasse 
      10, Munich, 80804, Germany.
FAU - Kaufmann, C
AU  - Kaufmann C
FAU - Grabner, A
AU  - Grabner A
FAU - Putz, B
AU  - Putz B
FAU - Wetter, T C
AU  - Wetter TC
FAU - Auer, D P
AU  - Auer DP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Basal Ganglia/pathology
MH  - *Brain Mapping
MH  - Cephalometry/statistics & numerical data
MH  - Cerebellum/pathology
MH  - Cerebral Cortex/*pathology
MH  - Cerebrospinal Fluid/physiology
MH  - Dominance, Cerebral/physiology
MH  - Female
MH  - Humans
MH  - Image Enhancement
MH  - *Image Processing, Computer-Assisted
MH  - *Imaging, Three-Dimensional
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Mathematical Computing
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
EDAT- 2001/04/17 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/04/17 10:00
PHST- 2001/04/17 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/04/17 10:00 [entrez]
AID - S1053-8119(01)90751-7 [pii]
AID - 10.1006/nimg.2001.0751 [doi]
PST - ppublish
SO  - Neuroimage. 2001 May;13(5):814-24. doi: 10.1006/nimg.2001.0751.