PMID- 11304742
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20071115
IS  - 0277-6715 (Print)
IS  - 0277-6715 (Linking)
VI  - 20
IP  - 8
DP  - 2001 Apr 30
TI  - Statistical cost-effectiveness analysis of two treatments based on net health 
      benefits.
PG  - 1279-302
AB  - Statistical methods for cost-effectiveness analysis (CEA) for two treatments that 
      mimic the deterministic optimal rules of CEA are presented. In these rules the 
      objective is to determine the treatment with the maximal effectiveness whose unit 
      cost is less than an amount, lambda, that a decision-maker is willing to pay 
      (WTP). This is accomplished by identifying the treatment with the largest 
      positive net health benefit (NHB), which is a function of lambda, while 
      controlling the familywise error rate both when the WTP value is given and when 
      it is unspecified. Fieller's theorem is used to determine a region of WTP values 
      where the NHBs of the treatments are not distinguishable. For each lambda outside 
      of the confidence region, the larger treatment is identified. A newly developed 
      one-tailed analogue of Fieller's theorem is used to determine the WTP values 
      where a treatment's NHB is positive. The situation in which both treatments are 
      experimental is distinguished from the case where one of the treatments is usual 
      care. The one-tailed confidence region is used in the latter case to obtain the 
      lambda values where the NHBs are not different, and determining the region of 
      positivity of the NHBs may be unnecessary. An example is presented in which the 
      cost-effectiveness of two antipsychotic treatments is evaluated.
CI  - Copyright 2001 John Wiley & Sons, Ltd.
FAU - Laska, E M
AU  - Laska EM
AD  - Statistical Sciences & Epidemiology Division, The Nathan S. Kline Institute for 
      Psychiatric Research, Orangeburg, New York 10962, USA. laska@nki.rfmh.org
FAU - Meisner, M
AU  - Meisner M
FAU - Siegel, C
AU  - Siegel C
FAU - Wanderling, J
AU  - Wanderling J
LA  - eng
GR  - MH 42959/MH/NIMH NIH HHS/United States
GR  - P50 MH 51359/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antipsychotic Agents/economics
MH  - Confidence Intervals
MH  - Cost-Benefit Analysis/*statistics & numerical data
MH  - Decision Trees
MH  - Humans
MH  - Mathematical Computing
MH  - Randomized Controlled Trials as Topic/*statistics & numerical data
MH  - Schizophrenia/economics
MH  - Software
MH  - Treatment Outcome
EDAT- 2001/04/17 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/04/17 10:00
PHST- 2001/04/17 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/04/17 10:00 [entrez]
AID - 10.1002/sim.774 [doi]
PST - ppublish
SO  - Stat Med. 2001 Apr 30;20(8):1279-302. doi: 10.1002/sim.774.