PMID- 11304864
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20191210
IS  - 0024-7758 (Print)
IS  - 0024-7758 (Linking)
VI  - 46
IP  - 3
DP  - 2001 Mar
TI  - Maternal serum tumor necrosis factor-alpha in patients with preterm labor.
PG  - 232-6
AB  - OBJECTIVE: To evaluate maternal serum tumor necrosis factor-alpha (TNF alpha) 
      levels in patients with preterm labor without clinical signs of chorioamnionitis 
      and to compare these with levels in nonlaboring controls. STUDY DESIGN: The study 
      group consisted of 44 patients with a singleton pregnancy admitted to our 
      department with the diagnosis of preterm labor between 26 and 36 weeks' 
      gestation. The control group consisted of 25 healthy consecutive patients with a 
      singleton pregnancy without preterm contractions who were seen for routine 
      antenatal visits. Maternal serum TNF alpha was measured using a solid-phase, 
      two-site chemiluminescent enzyme immunometric assay method, and levels were 
      compared in patients with preterm labor and nonlaboring controls. RESULTS: The 
      median maternal serum TNF alpha level for patients with preterm labor was 29.4 
      pg/mL (range, 12.3-173) as compared with 23 pg/mL (range, 11.9-62.7) in the 
      control group (P = .031). Among 44 patients with preterm labor, 14 (32%) 
      delivered within one week of admission. The median maternal serum TNF alpha level 
      was significantly higher in patients who delivered within one week than in those 
      who delivered after one week and controls (71.3 pg/mL [range, 28-173]) versus 22 
      pg/mL (range, 12.3-86) versus 23 pg/mL (range, 11.9-62.7) (P < .0001). 
      CONCLUSION: TNF alpha was elevated in patients with preterm labor, suggesting a 
      role for maternal serum TNF alpha in its initiation.
FAU - Gucer, F
AU  - Gucer F
AD  - Department of Obstetrics and Gynecology, School of Medicine, Trakya University, 
      22030 Edirne, Turkey. fgucer@yahoo.com
FAU - Balkanli-Kaplan, P
AU  - Balkanli-Kaplan P
FAU - Yuksel, M
AU  - Yuksel M
FAU - Yuce, M A
AU  - Yuce MA
FAU - Ture, M
AU  - Ture M
FAU - Yardim, T
AU  - Yardim T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Reprod Med
JT  - The Journal of reproductive medicine
JID - 0173343
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chorioamnionitis/blood/complications
MH  - Female
MH  - Humans
MH  - Obstetric Labor, Premature/*blood/etiology
MH  - Pregnancy
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2001/04/18 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/04/18 10:00
PHST- 2001/04/18 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/04/18 10:00 [entrez]
PST - ppublish
SO  - J Reprod Med. 2001 Mar;46(3):232-6.