PMID- 11306626
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 8
DP  - 2001 Apr 15
TI  - Spatiotemporal dynamics of brain-derived neurotrophic factor mRNA induction in 
      the vestibulo-olivary network during vestibular compensation.
PG  - 2738-48
AB  - Vestibular compensation, which is the behavioral recovery from vestibular 
      dysfunction produced by unilateral labyrinthectomy (UL), is attributed to 
      functional and structural reorganization of neural networks in the central 
      vestibular system. To assess the possible contribution of brain-derived 
      neurotrophic factor (BDNF) to this recovery process, we investigated changes in 
      mRNA expression levels in the central vestibular system after UL. We evaluated 
      BDNF mRNA expression levels by quantitative reverse transcription-PCR and in situ 
      hybridization. We found that BDNF mRNA is differentially induced in the medial 
      vestibular nucleus ipsilateral to UL and in the prepositus hypoglossi and 
      inferior olive on the contralateral side. The BDNF mRNA induction lasted for at 
      least 24 hr and returned to the basal expression level within 72 hr after UL. In 
      contrast to BDNF mRNA induction, the expression of an immediate-early gene, 
      c-fos, quickly reached the maximum level at 3 hr and decreased to the basal level 
      within 24 hr after UL. Neither BDNF or c-fos induction was observed in 
      sham-operated animals. The persistent induction of BDNF after UL temporally 
      corresponded to early behavioral manifestations of vestibular compensation. We 
      further found that trkB mRNA was expressed in the central vestibular network at 
      high levels, although its expression levels did not change over time after UL. 
      Because BDNF is implicated in regulating synaptic structure and function, these 
      results provide support for the hypothesis that BDNF is involved in neuronal 
      reorganization that allows vestibular compensation.
FAU - Li, Y X
AU  - Li YX
AD  - Mind Articulation Project, International Cooperative Research Project, Japan 
      Science and Technology Corporation, Yushima, Tokyo 113-0034, Japan.
FAU - Hashimoto, T
AU  - Hashimoto T
FAU - Tokuyama, W
AU  - Tokuyama W
FAU - Miyashita, Y
AU  - Miyashita Y
FAU - Okuno, H
AU  - Okuno H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - In Situ Hybridization
MH  - Male
MH  - Nerve Net/cytology/*metabolism
MH  - Neuronal Plasticity/physiology
MH  - Olivary Nucleus/cytology/*metabolism
MH  - Otologic Surgical Procedures
MH  - Proto-Oncogene Proteins c-fos/biosynthesis/genetics
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Vestibule, Labyrinth/cytology/innervation/*metabolism
PMC - PMC6762513
EDAT- 2001/04/18 10:00
MHDA- 2001/06/08 10:01
PMCR- 2001/10/15
CRDT- 2001/04/18 10:00
PHST- 2001/04/18 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/04/18 10:00 [entrez]
PHST- 2001/10/15 00:00 [pmc-release]
AID - 21/8/2738 [pii]
AID - 5134 [pii]
AID - 10.1523/JNEUROSCI.21-08-02738.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 Apr 15;21(8):2738-48. doi: 10.1523/JNEUROSCI.21-08-02738.2001.