PMID- 11308077
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20091119
IS  - 1050-4648 (Print)
IS  - 1050-4648 (Linking)
VI  - 11
IP  - 2
DP  - 2001 Feb
TI  - Rainbow trout offspring with different resistance to viral haemorrhagic 
      septicaemia.
PG  - 155-67
AB  - To study immunological and immunogenetical parameters related to resistance 
      against viral haemorrhagic septicaemia (VHS), attempts to make gynogenetic 
      strains of rainbow trout selected for high and low resistance to VHS were 
      initiated in 1988. The first gynogenetic generation of inbreeding resulted in the 
      more resistant offspring E8 and the low resistance offspring K3; the K3 offspring 
      having the same high mortality as the susceptible reference strain of outbred 
      trout in infection trials. A second gynogenetic generation derived from the E8 
      strain resulted in some low resistance offspring, and two gynogenetic families in 
      which all, or nearly all, fish survived challenge with VHS virus. In this study, 
      an attempt to associate the distribution of different MHC class II genotypes with 
      low and high resistance gynogenetic offspring was performed. Two different MHC 
      haplotypes could be distinguished, and in both low and high resistance families 
      all three genotypes were found, which could be explained by the fact that the 
      mother fish carried the heterozygous genotype. Although no significant 
      differences in MHC II genotypes were found between the high and low resistance 
      offspring, a significantly different distribution of haplotypes in the low 
      resistance offspring was observed, that could not be explained by a one- or 
      two-locus model.
FAU - Slierendrecht, W J
AU  - Slierendrecht WJ
AD  - Danish Veterinary Laboratory, Hangovej, Aarhus. hes@biomar.dk
FAU - Olesen, N J
AU  - Olesen NJ
FAU - Juul-Madsen, H R
AU  - Juul-Madsen HR
FAU - Lorenzen, N
AU  - Lorenzen N
FAU - Henryon, M
AU  - Henryon M
FAU - Berg, P
AU  - Berg P
FAU - Sondergaard, J
AU  - Sondergaard J
FAU - Koch, C
AU  - Koch C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
SB  - IM
MH  - Animals
MH  - Breeding/methods
MH  - Female
MH  - Fish Diseases/*immunology/virology
MH  - Genes, MHC Class II/genetics
MH  - Genetic Predisposition to Disease/*classification
MH  - Genotype
MH  - Haplotypes
MH  - Male
MH  - Oncorhynchus mykiss/classification/*genetics/*immunology
MH  - Polymorphism, Restriction Fragment Length
MH  - Rhabdoviridae Infections/immunology/*veterinary/virology
MH  - Selection, Genetic
MH  - Spermatozoa/radiation effects
EDAT- 2001/04/20 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/04/20 10:00
PHST- 2001/04/20 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/04/20 10:00 [entrez]
AID - S1050-4648(00)90302-4 [pii]
AID - 10.1006/fsim.2000.0302 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2001 Feb;11(2):155-67. doi: 10.1006/fsim.2000.0302.