PMID- 11309784
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 93
IP  - 2
DP  - 2001 Apr 25
TI  - Clinicopathologic analysis of breast carcinoma with chromosomal aneusomy detected 
      by fluorescence in situ hybridization.
PG  - 165-70
AB  - BACKGROUND: The clinicopathologic characteristics of breast carcinoma with 
      chromosomal aneusomy detected by fluorescence in situ hybridization (FISH) have 
      yet to be clarified. METHODS: Fine-needle aspiration biopsy (FNAB) samples were 
      obtained from 113 breast tumors and were subjected to FISH analysis using 
      centromeric probes for chromosomes 1, 11, and 17 to study a numerical aberration 
      of these chromosomes and its correlation with various clinicopathologic features 
      of breast tumors. RESULTS: Polysomy was observed in 77.0%, 50.5%, and 37.2% of 
      breast carcinoma samples for chromosomes 1, 11, and 17, respectively, and 
      monosomy was observed in 1.8%, 8.8%, and 22.1% for chromosomes 1, 11, and 17, 
      respectively. High histologic grade showed a significant correlation (P < 0.05) 
      with polysomy of chromosome 11. Lymph node metastasis showed a significant 
      correlation (P < 0.05) with polysomy of all three chromosomes, and positivity of 
      lymph node metastasis increased as the number of polysomic chromosomes increased. 
      In addition, estrogen receptor negativity was correlated significantly (P < 0.05) 
      with monosomy of chromosome 17, and progesterone receptor negativity was 
      correlated significantly (P < 0.05) with polysomy of chromosomes 11 and 17. 
      CONCLUSIONS: Aneusomy of chromosome 1, 11, or 17 detected by FISH is correlated 
      significantly with various clinicopathologic features of breast carcinoma. 
      Because FISH analysis of chromosomal aneusomy can be done using FNAB samples, 
      this technique seems to have the potential to be used for a better, preoperative 
      definition of the biologic characteristics of breast tumors.
FAU - Tsukamoto, F
AU  - Tsukamoto F
AD  - Department of Surgical Oncology, Osaka University Medical School, Osaka, Japan.
FAU - Miyoshi, Y
AU  - Miyoshi Y
FAU - Egawa, C
AU  - Egawa C
FAU - Kasugai, T
AU  - Kasugai T
FAU - Takami, S
AU  - Takami S
FAU - Inazawa, J
AU  - Inazawa J
FAU - Noguchi, S
AU  - Noguchi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy, Needle
MH  - Breast Neoplasms/genetics/*pathology
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - *Monosomy
EDAT- 2001/04/20 10:00
MHDA- 2001/05/05 10:01
CRDT- 2001/04/20 10:00
PHST- 2001/04/20 10:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/04/20 10:00 [entrez]
AID - 10.1002/cncr.9024 [doi]
PST - ppublish
SO  - Cancer. 2001 Apr 25;93(2):165-70. doi: 10.1002/cncr.9024.