PMID- 11311214
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20220311
IS  - 0009-2797 (Print)
IS  - 0009-2797 (Linking)
VI  - 134
IP  - 2
DP  - 2001 Apr 16
TI  - Comparison of the elimination between perfluorinated fatty acids with different 
      carbon chain length in rats.
PG  - 203-16
AB  - Elimination in urine and feces was compared between four perfluorinated fatty 
      acids (PFCAs) with different carbon chain length. In male rats, 
      perfluoroheptanoic acid (PFHA) was rapidly eliminated in urine with the 
      proportion of 92% of the dose being eliminated within 120 h after an 
      intraperitoneal injection. Perfluorooctanoic acid (PFOA), perfluorononanoic acid 
      (PFNA) and perfluorodecanoic acid (PFDA) was eliminated in urine with the 
      proportions of 55, 2.0 and 0.2% of the dose, respectively. By contrast, four 
      PFCAs were eliminated in feces with the proportion of less than 5% of the dose 
      within 120 h after an injection. In female rats, the proportions of PFOA and PFNA 
      eliminated in urine within 120 h were 80% and 51% of the dose, respectively, 
      which were significantly higher compared with those in male rats. There was the 
      tendency that PFCA with longer carbon chain length is less eliminated in urine in 
      both male and female rats. Fecal elimination of PFCAs was not different between 
      PFCAs in female rats and comparable to those in male rats. The rates of biliary 
      excretion of PFCAs in male rats were slower than those in female rats. 
      Sex-related difference in urinary elimination of PFOA was abolished when male 
      rats had been castrated. On the contrary, treatment with testosterone suppressed 
      the elimination of PFOA in urine in both castrated male rats and female rats. The 
      effect of testosterone was in a time- and dose-dependent manner. These results 
      suggest that PFCAs are distinguished by their carbon chain length by a renal 
      excretion system, which is regulated by testosterone.
FAU - Kudo, N
AU  - Kudo N
AD  - Faculty of Pharmaceutical Sciences, Josai University, Keyakidai 1-1, Sakado, 
      350-0295, Saitama, Japan. naokudo@josai.ac.jp
FAU - Suzuki, E
AU  - Suzuki E
FAU - Katakura, M
AU  - Katakura M
FAU - Ohmori, K
AU  - Ohmori K
FAU - Noshiro, R
AU  - Noshiro R
FAU - Kawashima, Y
AU  - Kawashima Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Caprylates)
RN  - 0 (Decanoic Acids)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 335-76-2 (perfluorodecanoic acid)
RN  - 375-85-9 (perfluoro-n-heptanoic acid)
RN  - 3XMK78S47O (Testosterone)
RN  - 76-21-1 (hexadecafluoro-nonanoic acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
SB  - IM
MH  - Animals
MH  - Bile/metabolism
MH  - Caprylates/pharmacokinetics
MH  - Decanoic Acids/pharmacokinetics
MH  - Fatty Acids/blood/*pharmacokinetics/toxicity/urine
MH  - Feces/chemistry
MH  - Female
MH  - Fluorocarbons/pharmacokinetics
MH  - Heptanoic Acids/pharmacokinetics
MH  - Hydrocarbons, Fluorinated/blood/*pharmacokinetics/toxicity/urine
MH  - Kidney/drug effects/metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Orchiectomy
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Characteristics
MH  - Testosterone/pharmacology
EDAT- 2001/04/20 10:00
MHDA- 2001/06/02 10:01
CRDT- 2001/04/20 10:00
PHST- 2001/04/20 10:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2001/04/20 10:00 [entrez]
AID - S0009-2797(01)00155-7 [pii]
AID - 10.1016/s0009-2797(01)00155-7 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2001 Apr 16;134(2):203-16. doi: 
      10.1016/s0009-2797(01)00155-7.