PMID- 11312308
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 9
DP  - 2001 May 1
TI  - The role of dopamine in the nucleus accumbens and striatum during sexual behavior 
      in the female rat.
PG  - 3236-41
AB  - Dopamine in dialysate from the nucleus accumbens (NAcc) increases during sexual 
      and feeding behavior and after administration of drugs of abuse, even those that 
      do not directly activate dopaminergic systems (e.g., morphine or nicotine). These 
      findings and others have led to hypotheses that propose that dopamine is 
      rewarding, predicts that reinforcement will occur, or attributes incentive 
      salience. Examining increases in dopamine in NAcc or striatum during sexual 
      behavior in female rats provides a unique situation to study these relations. 
      This is because, for the female rat, sexual behavior is associated with an 
      increase in NAcc dopamine and conditioned place preference only under certain 
      testing conditions. This experiment was conducted to determine what factors are 
      important for the increase in dopamine in dialysate from NAcc and striatum during 
      sexual behavior in female rats. The factors considered were the number of 
      contacts by the male, the timing of contacts by the male, or the ability of the 
      female to control contacts by the male. The results indicate that increased NAcc 
      dopamine is dependent on the timing of copulatory stimuli, independent of whether 
      the female rat is actively engaged in regulating this timing. For the striatum, 
      the timing of copulatory behavior influences the magnitude of the increase in 
      dopamine in dialysate, but other factors are also involved. We conclude that 
      increased extracellular dopamine in the NAcc and striatum conveys qualitative or 
      interpretive information about the rewarding value of stimuli. Sexual behavior in 
      the female rat is proposed as a model to determine the role of dopamine in 
      motivated behavior.
FAU - Becker, J B
AU  - Becker JB
AD  - Psychology Department, and Reproductive Sciences Program and Neuroscience 
      Program, The University of Michigan, Ann Arbor, Michigan 48109, USA. 
      jbbecker@umich.edu
FAU - Rudick, C N
AU  - Rudick CN
FAU - Jenkins, W J
AU  - Jenkins WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/analysis/metabolism
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Corpus Striatum/*metabolism
MH  - Dopamine/analysis/*metabolism
MH  - Estradiol/analogs & derivatives/pharmacology
MH  - Extracellular Space/chemistry/metabolism
MH  - Female
MH  - Homovanillic Acid/analysis/metabolism
MH  - Male
MH  - Microdialysis
MH  - Motivation
MH  - Nucleus Accumbens/*metabolism
MH  - Ovariectomy
MH  - Periodicity
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reaction Time/physiology
MH  - Sexual Behavior, Animal/drug effects/*physiology
PMC - PMC6762549
EDAT- 2001/04/20 10:00
MHDA- 2001/06/08 10:01
PMCR- 2001/11/01
CRDT- 2001/04/20 10:00
PHST- 2001/04/20 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/04/20 10:00 [entrez]
PHST- 2001/11/01 00:00 [pmc-release]
AID - 21/9/3236 [pii]
AID - 5164 [pii]
AID - 10.1523/JNEUROSCI.21-09-03236.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 May 1;21(9):3236-41. doi: 10.1523/JNEUROSCI.21-09-03236.2001.