PMID- 11314864
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20071115
IS  - 0091-7370 (Print)
IS  - 0091-7370 (Linking)
VI  - 31
IP  - 1
DP  - 2001 Jan
TI  - Detection of trisomy 8 in philadelphia chromosome-positive CML patients using 
      conventional cytogenetic and interphase fluorescence in situ hybridization 
      techniques and its relation to c-myc involvement.
PG  - 68-74
AB  - Trisomy 8 (+8) is a common clonal evolution marker for progression in chronic 
      myelogenous leukemia. The relationship of +8 to various stages of t(9;22) 
      leukemias is not firmly established. To explore this association we examined bone 
      marrow (BM) cells from 10 Philadelphia chromosome positive (Ph+) chronic myeloid 
      leukemia (CML) patients in different stages of the disease, using conventional 
      cytogenetic technique(CCT) and interphase fluorescence in situ hybridization 
      (FISH). FISH detection of chromosome 8 was accomplished using the D8Z2 (Oncor) 
      probe specific for the centrometric region of chromosome 8. Five hundred 
      interphase nuclei were counted for each patient. Three of the 10 patients were 
      selected for detection of c-myc gene locus located in the 8q24.2-24.3 region 
      using the L
FAU - Oudat, R
AU  - Oudat R
AD  - Department of Hematopathology, The University of Texas, M. D. Anderson Cancer 
      Center, Houston 77030-4095, USA.
FAU - Khan, Z
AU  - Khan Z
FAU - Glassman, A B
AU  - Glassman AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow Cells/pathology
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Genes, myc
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Translocation, Genetic
MH  - *Trisomy
EDAT- 2001/04/21 10:00
MHDA- 2001/05/18 10:01
CRDT- 2001/04/21 10:00
PHST- 2001/04/21 10:00 [pubmed]
PHST- 2001/05/18 10:01 [medline]
PHST- 2001/04/21 10:00 [entrez]
PST - ppublish
SO  - Ann Clin Lab Sci. 2001 Jan;31(1):68-74.