PMID- 11315272
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20191104
IS  - 0179-0358 (Print)
IS  - 0179-0358 (Linking)
VI  - 17
IP  - 2-3
DP  - 2001 Mar
TI  - Mast-cells distribution and colonic mucin composition in Hirschsprung's disease 
      and intestinal neuronal dysplasia.
PG  - 136-9
AB  - Intestinal neuronal dysplasia (IND) is a malformation of the enteric plexus that 
      clinically resembles Hirschsprung's disease (HD). In HD, the aganglionic bowel is 
      characterized by the presence of hypertrophic nerve trunks and increased numbers 
      of adrenergic and cholinergic nerve fibers, whereas IND type B (IND-B) is 
      characterized by dysplasia of parasympathetic nerves, hyperganglionosis, and 
      giant ganglia. The aims of this study were to investigate the relationship 
      between the distribution of mast cells (MC) and abnormal neuronal innervation and 
      the impact of abnormal neuronal innervation on colonic epithelial differentiation 
      in relation to the typical innervation abnormalities seen in HD and IND. 
      Full-thickness rectal-biopsy or resected surgical specimens from 15 patients (7 
      HD, 4 IND, 4 control) were examined by conventional hematoxylin-eosin, periodic 
      acid-Schiff Alcian blue (PAS-AB), toluidine blue staining. The aganglionic and 
      IND-B segments had larger numbers of MC in all layers than the ganglionic and 
      control segments. There was a close relationship between the hypertrophic nerve 
      fibers and the distribution of the MC. In contrast to the aganglionic segments, 
      the mucin composition of the IND-B segments was normal. This finding suggests 
      that innervation anomalies do not reflect epithelial differentiation to the same 
      extent.
FAU - Demirbilek, S
AU  - Demirbilek S
AD  - Department of Pediatric Surgery, Harran University School of Medicine, Sanliurja, 
      Turkey.
FAU - Ozardali, H I
AU  - Ozardali HI
FAU - Aydm, G
AU  - Aydm G
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 0 (Mucins)
SB  - IM
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Enteric Nervous System/*pathology
MH  - Female
MH  - Hirschsprung Disease/*pathology/surgery
MH  - Humans
MH  - Hyperplasia
MH  - Infant
MH  - Male
MH  - Mast Cells/*pathology
MH  - Mucins/*ultrastructure
MH  - Nerve Fibers/pathology
MH  - Rectum/innervation/pathology
EDAT- 2001/04/24 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/04/24 10:00
PHST- 2001/04/24 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/04/24 10:00 [entrez]
AID - 10.1007/s003830000467 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2001 Mar;17(2-3):136-9. doi: 10.1007/s003830000467.