PMID- 11315312
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20191104
IS  - 0179-0358 (Print)
IS  - 0179-0358 (Linking)
VI  - 17
IP  - 2-3
DP  - 2001 Mar
TI  - Investigation of the intra-abdominal oesophagus and hiatus in fetal rats with 
      oesophageal atresia and tracheo-oesophageal fistula.
PG  - 97-100
AB  - After surgical management of their oesophageal atresia (OA) and 
      tracheo-oesophageal fistula (TOF), most patients exhibit evidence of 
      gastro-oesophageal reflux (GOR) and many have oesophagitis. However, the 
      aetiology of the GOR is still controversial. This study was undertaken to 
      document whether there are congenital abnormalities in the intra-abdominal 
      oesophagus and the hiatus in the fetal rat with OA and TOF following exposure to 
      adriamycin (ADR). Time-pregnant rats were injected daily with either saline or 2 
      mg/kg ADR intraperitoneally on gestational days (GD) 6-9. The fetuses (n = 56) 
      from 8 litters were harvested on GD 21 for examination. The length of the 
      oesophagus between the diaphragmatic crura and the gastro-oesophageal junction 
      (GOJ) and the sizes of the stomach and the oesophageal hiatus were measured under 
      a dissecting microscope. The length of the oesophagus between the diaphragmatic 
      crura and the GOJ in the ADR-treated fetuses (0.85 +/- 0.37 mm) was significantly 
      shorter than in control fetuses (2.41 +/- 0.32 mm) (P < 0.0001). The size of the 
      stomach in ADR-treated fetuses (5.30 +/- 1.01 mm) was significantly smaller than 
      in the controls (8.07 +/- 0.49 mm) (P < 0.001). Moreover, the size of the 
      oesophageal hiatus in ADR-treated fetuses (1.16 +/- 0.43 mm) was markedly larger 
      than in the controls (0.32 +/- 0.1 mm) (P < 0.0001). These results showed that 
      the congenital abnormalities in ADR-treated rat fetuses may account for the 
      oesophageal functional disorders seen after surgical correction in patients who 
      have OA and TOF.
FAU - Zhou, B
AU  - Zhou B
AD  - F. Douglas Stephens Surgical Research Laboratory, Royal Children's Hospital 
      Research Institute, Melbourne, Australia.
FAU - Hutson, J M
AU  - Hutson JM
FAU - Myers, N A
AU  - Myers NA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 80168379AG (Doxorubicin)
SB  - IM
CIN - Pediatr Surg Int. 2004 Oct;20(10):813. PMID: 15243772
MH  - Abnormalities, Drug-Induced/pathology/surgery
MH  - Animals
MH  - Disease Models, Animal
MH  - Doxorubicin
MH  - Esophageal Atresia/*pathology/surgery
MH  - Female
MH  - Gastroesophageal Reflux/pathology
MH  - Gestational Age
MH  - Hernia, Hiatal/*pathology
MH  - Postoperative Complications/pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tracheoesophageal Fistula/*pathology/surgery
EDAT- 2001/04/24 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/04/24 10:00
PHST- 2001/04/24 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/04/24 10:00 [entrez]
AID - 10.1007/s003830000456 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2001 Mar;17(2-3):97-100. doi: 10.1007/s003830000456.