PMID- 11316107
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20220318
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 95
IP  - 4
DP  - 2001 Apr
TI  - Secular trends of allergic asthma in Danish adults. The Copenhagen Allergy Study.
PG  - 258-64
AB  - Numerous studies have reported increases in asthma prevalence among children 
      world-wide. Less is known about similar trends in adults. We aimed to investigate 
      whether the prevalence of allergic asthma symptoms had increased in an adult 
      general population. Two cross-sectional surveys using identical methods were 
      carried out in 1989 and 1998. A one-page questionnaire on respiratory symptoms 
      was mailed to random samples of 15-41-year-olds living in Copenhagen. The 
      response rates were 86.6% (3624/4185) and 78.8% (2402/3048) in 1989 and 1998, 
      respectively. The questionnaire was validated with specific immunoglobilin E 
      (IgE) positivity as the reference in a random sample of responders in connection 
      with both surveys. We found a significantly increased prevalence of subjects who 
      reported shortness of breath on exposure to pollens (6.6% 0 s. 10.3%, odds ratio 
      1.61, 95% CI 1.34-1.95), furry animals (5.4% vs. 7.6%, odds ratio 1.45, 95% CI 
      1.17-1.79), and house dust (7.8% vs. 10.2%, odds ratio 1.35, 95% CI 1.12-1.61). 
      The validation of these symptoms showed that the positive predictive values were 
      reasonably stable over time, which may support that a true increase in allergic 
      asthma has occurred. In conclusion, the prevalence of allergic asthma symptoms 
      increased significantly in this adult general population over a 9-year period.
FAU - Linneberg, A
AU  - Linneberg A
AD  - Centre for Preventive Medicine, Department of Internal Medicine M, Glostrup 
      Hospital, Denmark. alli@glostruphosp.dk
FAU - Nielsen, N H
AU  - Nielsen NH
FAU - Madsen, F
AU  - Madsen F
FAU - Frolund, L
AU  - Frolund L
FAU - Dirksen, A
AU  - Dirksen A
FAU - Jorgensen, T
AU  - Jorgensen T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Animals
MH  - Animals, Domestic/immunology
MH  - Asthma/*epidemiology/immunology
MH  - Cats
MH  - Confidence Intervals
MH  - Cross-Sectional Studies
MH  - Denmark/epidemiology
MH  - Dogs
MH  - Dust
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Logistic Models
MH  - Male
MH  - Odds Ratio
MH  - Pollen/immunology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Rhinitis, Allergic, Perennial/epidemiology
MH  - Rhinitis, Allergic, Seasonal/epidemiology
EDAT- 2001/04/24 10:00
MHDA- 2001/05/18 10:01
CRDT- 2001/04/24 10:00
PHST- 2001/04/24 10:00 [pubmed]
PHST- 2001/05/18 10:01 [medline]
PHST- 2001/04/24 10:00 [entrez]
AID - S0954-6111(01)91031-5 [pii]
AID - 10.1053/rmed.2001.1031 [doi]
PST - ppublish
SO  - Respir Med. 2001 Apr;95(4):258-64. doi: 10.1053/rmed.2001.1031.