PMID- 11317684
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20190921
IS  - 0936-8051 (Print)
IS  - 0936-8051 (Linking)
VI  - 121
IP  - 4
DP  - 2001
TI  - Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early 
      reperfusion-independent inflammatory events in hemorrhagic shock.
PG  - 219-22
AB  - Hemorrhagic shock (HS) initiates an inflammatory response that includes increased 
      expression of inducible nitric oxide synthase (iNOS) and production of 
      prostaglandins. Induction of iNOS during the ischemic phase of HS may involve the 
      activation of the hypoxia-inducible factor-1 (HIF-1). Increased expression of 
      cyclooxygenase-2 (COX-2) during HS contributes to prostaglandin production. The 
      aim of this study was to determine whether the ischemic phase of HS results in 
      the activation of HIF-1 and the induction of COX-2. The lungs of rats subjected 
      to HS demonstrated a twofold increase in HIF-1 activation (P < 0.01) and a 
      7.4-fold increase in expression of COX-2 mRNA (P < 0.01) compared with sham 
      controls. The upregulation of iNOS and COX-2 during ischemia are two important 
      early response genes that promote the inflammatory response and may contribute to 
      organ damage through the rapid and exaggerated production of nitric oxide and 
      prostaglandins.
FAU - Hierholzer, C
AU  - Hierholzer C
AD  - Department of Surgery, University of Pittsburgh School of Medicine, University of 
      Pittsburgh Medical Center, Pittsburgh, PA, USA.
FAU - Harbrecht, B G
AU  - Harbrecht BG
FAU - Billiar, T R
AU  - Billiar TR
FAU - Tweardy, D J
AU  - Tweardy DJ
LA  - eng
GR  - R01 DK055664/DK/NIDDK NIH HHS/United States
GR  - CA 72261/CA/NCI NIH HHS/United States
GR  - GM 53789/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Arch Orthop Trauma Surg
JT  - Archives of orthopaedic and trauma surgery
JID - 9011043
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hif1a protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Isoenzymes)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - Animals
MH  - Cyclooxygenase 2
MH  - DNA-Binding Proteins/*genetics
MH  - Enzyme Induction/genetics
MH  - Gene Expression/physiology
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Isoenzymes/*genetics
MH  - Lung/*blood supply/pathology
MH  - Male
MH  - Nuclear Proteins/*genetics
MH  - Prostaglandin-Endoperoxide Synthases/*genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/pathology/*physiopathology
MH  - Shock, Hemorrhagic/pathology/*physiopathology
MH  - Systemic Inflammatory Response Syndrome/pathology/*physiopathology
MH  - *Transcription Factors
MH  - Up-Regulation/genetics
EDAT- 2001/04/25 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/04/25 10:00
PHST- 2001/04/25 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/04/25 10:00 [entrez]
AID - 10.1007/s004020000211 [doi]
PST - ppublish
SO  - Arch Orthop Trauma Surg. 2001;121(4):219-22. doi: 10.1007/s004020000211.