PMID- 11319056
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20061115
IS  - 0885-114X (Print)
IS  - 0885-114X (Linking)
VI  - 16
IP  - 2
DP  - 2001 Apr-Jun
TI  - Cytogenetic assays for monitoring populations exposed to environmental mutagens.
PG  - 345-57
AB  - A variety of cytogenetic assays have been used successfully for monitoring 
      populations exposed to environmental mutagens. The traditional chromosome 
      aberration (CA) assay is one of the most useful, and it also predicts cancer 
      outcome on a population basis. However, the sensitivity of this assay requires 
      improvement, and researchers need to understand other factors that influence the 
      expression of CA and health outcome, especially on an individual basis. The 
      sensitivity and specificity of the CA assay are improved with the use of the 
      fluorescence in situ hybridization (FISH) procedure, which employs a variety of 
      chromosome-specific and chromosome region-specific fluorescence probes to 
      elucidate CA. Factors that influence the expression of CA in a population study 
      include inadequate study design, genetic variations in metabolism of chemicals 
      (genetic susceptibility), and lifestyle differences in response to exposure to 
      environmental mutagens (acquired susceptibility). The latter may involve previous 
      or concurrent exposure to environmental mutagens, e.g., cigarette smoking habits.
FAU - Au, W W
AU  - Au WW
AD  - Department of Preventive Medicine and Community Health, University of Texas 
      Medical Branch, Galveston 77555-1110, USA.
FAU - Badary, O A
AU  - Badary OA
FAU - Heo, M Y
AU  - Heo MY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Occup Med
JT  - Occupational medicine (Philadelphia, Pa.)
JID - 8605629
RN  - 0 (Mutagens)
SB  - IM
MH  - *Chromosome Aberrations/genetics
MH  - *Cytogenetic Analysis/methods
MH  - Disease Susceptibility
MH  - *Environmental Exposure
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Life Style
MH  - Micronucleus Tests
MH  - *Mutagenicity Tests
MH  - Mutagens
MH  - Polymorphism, Genetic
RF  - 79
EDAT- 2001/04/25 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/04/25 10:00
PHST- 2001/04/25 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/04/25 10:00 [entrez]
PST - ppublish
SO  - Occup Med. 2001 Apr-Jun;16(2):345-57.