PMID- 11319771
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20071114
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 64
IP  - 3
DP  - 2001 May 1
TI  - Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing 
      brain-derived neurotrophic factor.
PG  - 268-76
AB  - Excess neuronal activity upregulates the expression of two neurotrophins, nerve 
      growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in adult 
      hippocampus. Nerve growth factor has been shown to contribute the induction of 
      aberrant hippocampal mossy fiber sprouting in the inner molecular layer of the 
      dentate gyrus, however the role of prolonged brain-derived neurotrophic factor 
      exposure is uncertain. We examined the distribution and plasticity of mossy 
      fibers in transgenic mice with developmental overexpression of brain-derived 
      neurotrophic factor. Despite 2--3-fold elevated BDNF levels in the hippocampus 
      sufficient to increase the intensity of neuropeptide Y immunoreactivity in 
      interneurons, no visible changes in mossy fiber Timm staining patterns were 
      observed in the inner molecular layer of adult mutant hippocampus compared to 
      wild-type mice. In addition, no changes of the mRNA expression of two 
      growth-associated proteins, GAP-43 and SCG-10 were found. These data suggest that 
      early and persistent elevations of brain-derived neurotrophic factor in granule 
      cells are not sufficient to elicit this pattern of axonal plasticity in the 
      hippocampus.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Qiao, X
AU  - Qiao X
AD  - Department of Cellular Biology and Anatomy, Louisiana State University Health 
      Science Center, Shreveport, Louisiana 71130-3932, USA. xqiao@lsuhsc.edu
FAU - Suri, C
AU  - Suri C
FAU - Knusel, B
AU  - Knusel B
FAU - Noebels, J L
AU  - Noebels JL
LA  - eng
GR  - NS09985/NS/NINDS NIH HHS/United States
GR  - NS29709/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Neuropeptide Y)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - GAP-43 Protein/*metabolism
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Mossy Fibers, Hippocampal/*metabolism
MH  - Neuropeptide Y/*metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
EDAT- 2001/04/25 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/04/25 10:00
PHST- 2001/04/25 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/04/25 10:00 [entrez]
AID - 10.1002/jnr.1075 [doi]
PST - ppublish
SO  - J Neurosci Res. 2001 May 1;64(3):268-76. doi: 10.1002/jnr.1075.