PMID- 11320564
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20120620
IS  - 0867-7077 (Print)
IS  - 0867-7077 (Linking)
VI  - 68
IP  - 11-12
DP  - 2000
TI  - [Polymorphism of histocompatibility class II antigens coded with the DRB gene in 
      in familial sarcoidosis in Poland].
PG  - 533-44
AB  - Several studies suggested association between some human leukocyte antigen (HLA) 
      alleles and sarcoidosis, but none has been conclusive. To confirm possible 
      association of sarcoidosis with HLA-DRB1, -DRB3,- DRB4, -DRB5 associated alleles 
      HLA-DR genotyping was performed using polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) method in 17 polish families with 
      familial sarcoidosis and in 101 healthy controls. The families with sarcoidosis 
      consisted of 31 affected first-degree relatives from 16 families, 2 affected 
      cousins from 1 family and 78 healthy relatives of those patients. We found 3 
      varieties of familial sarcoidosis: a) in parent and offspring (5 pairs), b) in 
      siblings (10 sib pairs and 1 sib triplet) and in cousins (1 family). Genotyping 
      for HLA-DRB1,-DRB3,-DRB4,-DRB5 revealed an over-representation of HLA-DR5(12) and 
      DRw52 among antigens shared by affected relatives comparing to the control group. 
      A significant increase in the frequency of HLA-DR7 and HLA-DRw53 antigens (p < 
      0.05) was found in subjects from the control group. Comparing the group of family 
      members (affected and healthy relatives taken together, n = 111) with the control 
      group (n = 101) we found a significant differences in the distribution of 
      HLA-DR2(15), HLA-DR5(12), HLA-DR6, HLA-DR9 and HLA-DRw52. Those antigens were 
      more frequent (p < 0.05) in members from families with sarcoidosis. The 
      frequencies of HLA-DR1, HLA-DR2(16), HLA-DR7 and HLA-DRw53 were significantly 
      higher (p < 0.05) in the control group. Presented results suggest that HLA-DRB 
      alleles contribute to the susceptibility to sarcoidosis in the Polish population.
FAU - Goljan, A
AU  - Goljan A
AD  - Kliniki Chorob Pluc Instytutu Gruzlicy i Chorob Pluc, Warszawie.
FAU - Puscinska, E
AU  - Puscinska E
FAU - Sankowska, M
AU  - Sankowska M
FAU - Zielinski, J
AU  - Zielinski J
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Polimorfizm ukladu antygenow zgodnosci tkankowej klasy II kodowanych genem DRB w 
      sarkoidozie rodzinnej w Polsce.
PL  - Poland
TA  - Pneumonol Alergol Pol
JT  - Pneumonologia i alergologia polska
JID - 9302892
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Poland/epidemiology
MH  - *Polymorphism, Genetic
MH  - Sarcoidosis/epidemiology/*genetics/immunology
MH  - Serotyping
EDAT- 2001/04/26 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/04/26 10:00
PHST- 2001/04/26 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/04/26 10:00 [entrez]
PST - ppublish
SO  - Pneumonol Alergol Pol. 2000;68(11-12):533-44.