PMID- 11325688
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190815
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 37
IP  - 5
DP  - 2001 May
TI  - Hemodialysis followed by continuous hemofiltration for treatment of lithium 
      intoxication in children.
PG  - 1044-7
AB  - Hemodialysis is the usual recommended treatment for severe lithium intoxication; 
      however, rebound of lithium levels may require repeated hemodialysis treatments. 
      We proposed that the addition of continuous hemofiltration after hemodialysis 
      would prevent rebound by providing ongoing clearance of lithium. We report two 
      pediatric patients with lithium intoxication treated by hemodialysis followed by 
      continuous venovenous hemofiltration with dialysis (CVVHD). Both patients were 
      symptomatic at presentation and had initial lithium levels more than three times 
      the usual therapeutic range. Hemodialysis followed by CVVHD resulted in rapid 
      resolution of symptoms, followed by continuous clearance of lithium without 
      requiring repeated hemodialysis sessions. Both patients had return of normal 
      mental status during CVVHD treatment, and neither patient experienced 
      complications of hemodialysis or CVVHD. Total duration of treatment with 
      hemodialysis followed by CVVHD was 34.5 hours for the first patient and 26 hours 
      for the second patient. We conclude that hemodialysis followed by CVVHD is a safe 
      and effective approach to the management of lithium intoxication in children.
FAU - Meyer, R J
AU  - Meyer RJ
AD  - Department of Pediatrics, Section of Pediatric Critical Care, University of 
      Arizona, Tucson, AZ, USA. rjmeyer@peds.arizona.edu
FAU - Flynn, J T
AU  - Flynn JT
FAU - Brophy, P D
AU  - Brophy PD
FAU - Smoyer, W E
AU  - Smoyer WE
FAU - Kershaw, D B
AU  - Kershaw DB
FAU - Custer, J R
AU  - Custer JR
FAU - Bunchman, T E
AU  - Bunchman TE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Antimanic Agents)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Adolescent
MH  - Antimanic Agents/blood/*poisoning
MH  - Female
MH  - Hemodiafiltration/*methods
MH  - Humans
MH  - Lithium/blood/*poisoning
MH  - Male
MH  - Poisoning/therapy
EDAT- 2001/04/28 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/04/28 10:00
PHST- 2001/04/28 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/04/28 10:00 [entrez]
AID - S0272-6386(05)80022-8 [pii]
AID - 10.1016/s0272-6386(05)80022-8 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2001 May;37(5):1044-7. doi: 10.1016/s0272-6386(05)80022-8.