PMID- 11327276
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20161124
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 28
IP  - 4
DP  - 2001 Apr
TI  - Minimal clinically important difference in plain films in RA: group discussions, 
      conclusions, and recommendations. OMERACT Imaging Task Force.
PG  - 914-7
AB  - Analysis of progression of structural damage on an individual patient level in 
      randomized controlled trials provides extra information in addition to the 
      analysis on a group level. A cutoff level is required to define which patients 
      show progression and which patients do not. The objective of the mimimal 
      clinically important difference (MCID) module for plain films was to elaborate 
      the various concepts to determine a MCID for plain films, and if possible, to 
      define a MCID for specific scoring methods. The module comprised preconference 
      reading material, a plenary session, small group discussions, and a plenary 
      report of the group sessions, combined with interactive voting. The following 
      conclusions and recommendations were made: the smallest detectable difference 
      (SDD) beyond measurement error is a good starting point to define MCID; SDD is 
      study-specific; SDD should be reported for all radiographic endpoints used in a 
      trial as a quality control; the expert panel approach is a reasonable method to 
      define MCID, but defined in this way MCID may be smaller than current SDD; more 
      research is needed to validate expert panel based MCID in different datasets and 
      with different experts; a predictive, data driven MCID is the ultimate goal, but 
      is not yet available; the SDD can be used as a proxy for MCID until a data driven 
      MCID is available; analysis at the group level (comparison of means or medians) 
      should remain primary in studies that include progression of joint damage as 
      outcome measure; the proportion of patients showing more progression than the SDD 
      is a secondary outcome measure.
FAU - van der Heijde, D
AU  - van der Heijde D
AD  - Department of Internal Medicine, University Hospital Maastricht, The Netherlands. 
      dhe@sint.azm.nl
FAU - Lassere, M
AU  - Lassere M
FAU - Edmonds, J
AU  - Edmonds J
FAU - Kirwan, J
AU  - Kirwan J
FAU - Strand, V
AU  - Strand V
FAU - Boers, M
AU  - Boers M
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
MH  - Arthritis, Rheumatoid/*diagnostic imaging
MH  - Arthrography/*methods
MH  - Disease Progression
MH  - Humans
EDAT- 2001/05/01 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/05/01 10:00
PHST- 2001/05/01 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/05/01 10:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 2001 Apr;28(4):914-7.