PMID- 11327458
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20220330
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 62
IP  - 4
DP  - 2001 Apr
TI  - Effects of intranasal inoculation with Bordetella bronchiseptica, porcine 
      reproductive and respiratory syndrome virus, or a combination of both organisms 
      on subsequent infection with Pasteurella multocida in pigs.
PG  - 521-5
AB  - OBJECTIVE: To determine effects of intranasal inoculation with porcine 
      reproductive and respiratory syndrome virus (PRRSV) or Bordetella bronchiseptica 
      on challenge with nontoxigenic Pasteurella multocida in pigs. ANIMALS: Seventy 
      3-week-old pigs. PROCEDURE: In experiment 1, pigs were not inoculated (n= 10) or 
      were inoculated with PRRSV (10), P. multocida (10), or PRRSV followed by 
      challenge with P. multocida (10). In experiment 2, pigs were not inoculated (n = 
      10) or were inoculated with B. bronchiseptica (10) or PRRSV and B. bronchiseptica 
      (10); all pigs were challenged with P. multocida. Five pigs from each group were 
      necropsied 14 and 21 days after initial inoculations. RESULTS: Pasteurella 
      multocida was not isolated from tissue specimens of pigs challenged with P. 
      multocida alone or after inoculation with PRRSV. However, in pigs challenged 
      after inoculation with B. bronchiseptica, P. multocida was isolated from 
      specimens of the nasal cavity and tonsil of the soft palate. Number of bacteria 
      isolated increased in pigs challenged after coinoculation with PRRSV and B. 
      bronchiseptica, and all 3 agents were isolated from pneumonic lesions in these 
      pigs. CONCLUSIONS AND CLINICAL RELEVANCE: Infection of pigs with B. 
      bronchiseptica but not PRRSV prior to challenge with P. multocida resulted in 
      colonization of the upper respiratory tract and tonsil of the soft palate with P. 
      multocida. Coinfection with PRRSV and B. bronchiseptica predisposed pigs to 
      infection of the upper respiratory tract and lung with P. multocida. Porcine 
      reproductive and respiratory syndrome virus and B. bronchiseptica may interact to 
      adversely affect respiratory tract defense mechanisms, leaving pigs especially 
      vulnerable to infection with secondary agents such as P. multocida.
FAU - Brockmeier, S L
AU  - Brockmeier SL
AD  - Respiratory Diseases of Livestock Research Unit, USDA, Agricultural Research 
      Service, National Animal Disease Center, Ames, IA 50010, USA.
FAU - Palmer, M V
AU  - Palmer MV
FAU - Bolin, S R
AU  - Bolin SR
FAU - Rimler, R B
AU  - Rimler RB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
SB  - IM
MH  - Animals
MH  - Bacteremia
MH  - Bordetella Infections/complications/microbiology/*veterinary
MH  - Bordetella bronchiseptica/*pathogenicity
MH  - Lung/microbiology/pathology
MH  - Nasal Cavity/microbiology
MH  - Palate, Soft/microbiology
MH  - Palatine Tonsil/microbiology
MH  - Pasteurella Infections/complications/pathology/*veterinary
MH  - Pasteurella multocida/*pathogenicity
MH  - Porcine Reproductive and Respiratory Syndrome/*microbiology
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Random Allocation
MH  - Swine
MH  - Swine Diseases/*microbiology/virology
MH  - Viremia
EDAT- 2001/05/01 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/05/01 10:00
PHST- 2001/05/01 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/05/01 10:00 [entrez]
AID - 10.2460/ajvr.2001.62.521 [doi]
PST - ppublish
SO  - Am J Vet Res. 2001 Apr;62(4):521-5. doi: 10.2460/ajvr.2001.62.521.