PMID- 11328790
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20190513
IS  - 0305-7453 (Print)
IS  - 0305-7453 (Linking)
VI  - 47
IP  - 5
DP  - 2001 May
TI  - Effect of LY333328 against vancomycin-resistant Enterococcus faecium in a rat 
      central venous catheter-associated infection model.
PG  - 705-7
AB  - A rat central venous catheter (CVC) infection model was used to assess the 
      activity of LY333328 against vancomycin-resistant Enterococcus faecium (VRE). Via 
      the CVC, animals were challenged with 10(6) cfu of Enterococcus faecium with the 
      VanA phenotype. Eight rats received a single dose of LY333328 and eight rats 
      received saline. Seventy-five per cent of control animals had peripheral 
      bacteraemia and 87.5% had VRE recovered from explanted CVCs at the time they were 
      killed, as compared with 0 and 12.5%, respectively, of the LY333328-treated 
      animals (P < 0.01). All animals in the control group had evidence of metastatic 
      disease compared with none of the treated group (P < 0.01). LY333328 was 
      effective against the strain of VRE tested in this model.
FAU - Rupp, M E
AU  - Rupp ME
AD  - Department of Internal Medicine, 984031 University of Nebraska Medical Center, 
      Omaha, NE 68198-4031, USA. merupp@unmc.edu
FAU - Fey, P D
AU  - Fey PD
FAU - Longo, G M
AU  - Longo GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glycopeptides)
RN  - 0 (Lipoglycopeptides)
RN  - PUG62FRZ2E (oritavancin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Catheters, Indwelling/microbiology
MH  - Disease Models, Animal
MH  - *Enterococcus faecium/drug effects
MH  - *Glycopeptides
MH  - Gram-Positive Bacterial Infections/*drug therapy
MH  - Lipoglycopeptides
MH  - Male
MH  - Prosthesis-Related Infections/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vancomycin Resistance
EDAT- 2001/05/01 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/05/01 10:00
PHST- 2001/05/01 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/05/01 10:00 [entrez]
AID - 10.1093/jac/47.5.705 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2001 May;47(5):705-7. doi: 10.1093/jac/47.5.705.