PMID- 11329185
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20191104
IS  - 0894-1491 (Print)
IS  - 0894-1491 (Linking)
VI  - 34
IP  - 3
DP  - 2001 May
TI  - Neuronal signals regulate neurotrophin expression in oligodendrocytes of the 
      basal forebrain.
PG  - 234-9
AB  - Previous studies suggest that oligodendrocytes express trophic molecules, 
      including neurotrophins. These molecules have been shown to influence nearby 
      neurons. To determine whether neuronal signals may, in turn, affect 
      oligodendrocyte-derived trophins, we examined regulation of nerve growth factor 
      (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA 
      expression in cultured oligodendrocytes of the basal forebrain. Neuronal signals 
      had distinct effects on individual neurotrophins. KCl elicited increases in BDNF 
      mRNA, but did not affect expression of NGF or NT-3. The cholinergic agonist, 
      carbachol, increased expression of NGF, but did not affect expression of BDNF or 
      NT-3. Glutamate elicited a decrease in BDNF, but did not affect expression of NGF 
      or NT-3. This glutamate effect is not due to toxicity, since the number of total 
      cells was unchanged, while the number of mature myelin basic protein positive 
      (MBP+) cells increased. Our observations suggest that individual neuronal signals 
      distinctly influence the trophic function of oligodendrocytes.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Dai, X
AU  - Dai X
AD  - Department of Neuroscience and Cell Biology, University of Medicine and Dentistry 
      of New Jersey/Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, 
      USA.
FAU - Qu, P
AU  - Qu P
FAU - Dreyfus, C F
AU  - Dreyfus CF
LA  - eng
GR  - 36647/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinergic Agonists)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 8Y164V895Y (Carbachol)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Basal Nucleus of Meynert/cytology/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Carbachol/pharmacology
MH  - Cell Communication/drug effects/*physiology
MH  - Cells, Cultured/cytology/drug effects/metabolism
MH  - Cholinergic Agonists/pharmacology
MH  - Gene Expression Regulation/drug effects/physiology
MH  - Glutamic Acid/pharmacology
MH  - Nerve Growth Factor/genetics
MH  - Nerve Growth Factors/*genetics
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Neurotrophin 3/genetics
MH  - Oligodendroglia/cytology/drug effects/*metabolism
MH  - Potassium/pharmacology
MH  - RNA, Messenger/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects/*physiology
EDAT- 2001/05/01 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/05/01 10:00
PHST- 2001/05/01 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/05/01 10:00 [entrez]
AID - 10.1002/glia.1057 [pii]
AID - 10.1002/glia.1057 [doi]
PST - ppublish
SO  - Glia. 2001 May;34(3):234-9. doi: 10.1002/glia.1057.