PMID- 11329943
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 105
IP  - 4
DP  - 2001 Apr
TI  - [The role of cytokines in the pathogenesis of diabetic retinopathy].
PG  - 213-7
AB  - PURPOSE: To investigate the role of cytokines and advanced glycation end 
      products(AGEs) in the pathogenesis of diabetic retinopathy, we measured vascular 
      endothelial growth factor(VEGF), interleukin-6(IL-6), tumor necrosis 
      factor-alpha(TNF-alpha), transforming growth factor-beta 1(TGF-beta 1), and 
      pentosidine(an AGE) levels in aqueous, vitreous, and paired plasma obtained from 
      diabetic patients. RESULTS: The aqueous levels of VEGF and IL-6 were positively 
      correlated with the grade of clinical severity of diabetic retinopathy (both VEGF 
      and IL-6, p < 0.001). Other cytokines and pentosidine levels were not 
      significantly associated. The aqueous levels of VEGF and IL-6 were higher than 
      the plasma levels(VEGF p = 0.02, IL-6 p < 0.001). CONCLUSION: Within the 
      intraocular area VEGF and IL-6 are produced and participate in the pathogenesis 
      of hyperpermeability of retinal vessels in preproliferative diabetic retinopathy.
FAU - Ohara, K
AU  - Ohara K
AD  - Department of Ophthalmology, Jikei University School of Medicine, 3-25-8 
      Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
FAU - Funatsu, H
AU  - Funatsu H
FAU - Kitano, S
AU  - Kitano S
FAU - Hori, S
AU  - Hori S
FAU - Yamashita, H
AU  - Yamashita H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
RN  - 0 (Cytokines)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Interleukin-6)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Cytokines/*physiology
MH  - Diabetic Retinopathy/*etiology
MH  - Endothelial Growth Factors/physiology
MH  - Female
MH  - Humans
MH  - Interleukin-6/physiology
MH  - Lymphokines/physiology
MH  - Male
MH  - Middle Aged
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 2001/05/02 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/05/02 10:00
PHST- 2001/05/02 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/05/02 10:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 2001 Apr;105(4):213-7.