PMID- 11330047
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20191104
IS  - 1085-9195 (Print)
IS  - 1085-9195 (Linking)
VI  - 32 Spring
DP  - 2000
TI  - PPAR-mediated diverse responses in various tissues of mouse.
PG  - 205-11
AB  - Peroxisome proliferator-activated receptors (PPARs) play the essential role in 
      transcriptional modulations of the genes involved in lipid metabolism. In vitro 
      studies have shown that all the mechanisms of the modulations are similarly 
      mediated by PPAR and the response elements through heterodimerization with 
      retinoid X receptors (RXRs). However, PPARs mediate the diverse effects induced 
      in various tissues of mouse by their activators. First, PPAR alpha also plays an 
      obligatory role in the activator-induced transcriptional modulations of various 
      genes, some of which are not related to lipid metabolism. Second, responsiveness 
      of various genes to several activators varies considerably. Third, some of the 
      activator-induced transcriptional activation of several genes is strictly 
      tissue-specific. Fourth, the time courses of the activator-induced 
      transcriptional modulations are diverse. Following brief review of these diverse 
      responses, emphasis is laid on the need for studies of these diversely regulated 
      genes to understand the species-general and coordinated interplay between PPARs 
      and other factors to maintain lipid homeostasis at the body level.
FAU - Motojima, K
AU  - Motojima K
AD  - Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, 
      Funabashi, Chiba 274-8510, Japan. motojima@phar.toho-u.ac.jp
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Lipid Metabolism
MH  - Male
MH  - Mice
MH  - Organ Specificity
MH  - Peroxisomes/*metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Signal Transduction
MH  - Transcription Factors/*metabolism
EDAT- 2001/05/02 10:00
MHDA- 2001/06/22 10:01
CRDT- 2001/05/02 10:00
PHST- 2001/05/02 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/05/02 10:00 [entrez]
AID - 10.1385/cbb:32:1-3:205 [doi]
PST - ppublish
SO  - Cell Biochem Biophys. 2000;32 Spring:205-11. doi: 10.1385/cbb:32:1-3:205.