PMID- 11330730
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20191104
IS  - 1341-8076 (Print)
IS  - 1341-8076 (Linking)
VI  - 27
IP  - 1
DP  - 2001 Feb
TI  - Rapid detection of chromosome aneuploidies by prenatal interphase FISH 
      (fluorescence in situ hybridization) and its clinical utility in Japan.
PG  - 41-7
AB  - OBJECTIVE: The purpose of this study was to assess the accuracy, informative 
      rate, detection rate, and clinical utility of prenatal interphase fluorescence in 
      situ hybridization (FISH) analysis of amniotic fluid samples from Japanese women. 
      METHODS: Amniotic fluid specimens from 2,639 Japanese women were received for 
      prenatal interphase FISH and chromosome analysis. A questionnaire was designed to 
      evaluate FISH clinical utility by collaboration sites. RESULTS: Based on 2,319 
      tested samples, the accuracy (100%), informative (94%), and detection (87.6%) 
      rates were all high. The accuracy (100%), informative (90.2%), and detection 
      (90.0%) rates were also remarkable in third-trimester pregnancies. We perceive 
      significant advantages from this test regarding medical management and patient 
      satisfaction. CONCLUSIONS: This novel report shows that in Japan prenatal 
      interphase FISH testing is highly informative and accurate, not only in 
      second-trimester pregnancies but also in third-trimester pregnancies. This test 
      provides advantages to both physicians and patients, provided that its 
      capabilities and limitations are understood.
FAU - Sawa, R
AU  - Sawa R
AD  - Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
FAU - Hayashi, Z
AU  - Hayashi Z
FAU - Tanaka, T
AU  - Tanaka T
FAU - Onda, T
AU  - Onda T
FAU - Hoshi, K
AU  - Hoshi K
FAU - Fukada, Y
AU  - Fukada Y
FAU - Takai, Y
AU  - Takai Y
FAU - Taketani, Y
AU  - Taketani Y
FAU - Kubo, T
AU  - Kubo T
FAU - Hamada, H
AU  - Hamada H
FAU - Yoshida, K
AU  - Yoshida K
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Okai, T
AU  - Okai T
FAU - Sakai, M
AU  - Sakai M
FAU - Kaneoka, T
AU  - Kaneoka T
FAU - Makino, Y
AU  - Makino Y
FAU - Aono, T
AU  - Aono T
FAU - Maeda, K
AU  - Maeda K
FAU - Honda, R
AU  - Honda R
FAU - Okamura, H
AU  - Okamura H
FAU - Sago, H
AU  - Sago H
FAU - Kitagawa, M
AU  - Kitagawa M
FAU - Minoura, S
AU  - Minoura S
FAU - Inaba, J
AU  - Inaba J
FAU - Terakawa, N
AU  - Terakawa N
FAU - Nagata, N
AU  - Nagata N
FAU - Shimomura, K
AU  - Shimomura K
FAU - Sapeta, M J
AU  - Sapeta MJ
FAU - Estabrooks, L L
AU  - Estabrooks LL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
SB  - IM
MH  - Adult
MH  - Amniotic Fluid
MH  - Chromosome Aberrations/*diagnosis
MH  - Chromosome Disorders
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Patient Satisfaction
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - Pregnancy Trimester, Third
MH  - *Prenatal Diagnosis
MH  - Surveys and Questionnaires
EDAT- 2001/05/02 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/05/02 10:00
PHST- 2001/05/02 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/05/02 10:00 [entrez]
AID - 10.1111/j.1447-0756.2001.tb01214.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2001 Feb;27(1):41-7. doi: 
      10.1111/j.1447-0756.2001.tb01214.x.