PMID- 11331420
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 77
IP  - 3
DP  - 2001 May
TI  - Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain 
      of depressed suicide subjects.
PG  - 916-28
AB  - The extracellular regulated kinases (ERK) 1 and ERK2 are members of 
      mitogen-activated protein (MAP) kinase family that play an important role in 
      transducing extracellular signals to the nucleus and have been implicated in a 
      broad spectrum of biological responses. To test the hypothesis that MAP kinases 
      may be involved in depression, we examined the activation of p44/42 MAP kinase 
      and expression of ERK1 and ERK2 in the post-mortem brain tissue obtained from 
      non-psychiatric control subjects (n = 11) and age- and the post-mortem 
      interval-matched depressed suicide subjects (n = 11). We observed that p44/42 MAP 
      kinase activity was significantly decreased in the prefrontal cortical areas 
      (Brodmann's areas 8, 9 and 10) and the hippocampus of depressed suicide subjects 
      without any change in the cerebellum. This decrease was associated with a 
      decrease in mRNA and protein levels of ERK1 and ERK2. In addition, the expression 
      of MAP kinase phosphatase (MKP)2, a 'dual function' ERK1/2 phosphatase, was 
      increased in the prefrontal cortex and hippocampus. These studies suggest that 
      p44/42 MAP kinases are less activated in the post-mortem brain of depressed 
      suicide subjects and this may be because of reduced expression of ERK1/2 and 
      increased expression of MKP2. Given the role of MAP kinases in various 
      physiological functions and gene expression, alterations in p44/42 MAP kinase 
      activation and expression of ERK1/2 may contribute significantly to the 
      pathophysiology of depressive disorders.
FAU - Dwivedi, Y
AU  - Dwivedi Y
AD  - Psychiatric Institute, Department of Psychiatry, University of Illinois at 
      Chicago, 60612, USA. ydwivedi@psych.uic.edu
FAU - Rizavi, H S
AU  - Rizavi HS
FAU - Roberts, R C
AU  - Roberts RC
FAU - Conley, R C
AU  - Conley RC
FAU - Tamminga, C A
AU  - Tamminga CA
FAU - Pandey, G N
AU  - Pandey GN
LA  - eng
GR  - KO1-01836/PHS HHS/United States
GR  - R01MH5628/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.1.3.16 (Mitogen-Activated Protein Kinase Phosphatases)
RN  - EC 3.1.3.48 (DUSP4 protein, human)
RN  - EC 3.1.3.48 (Dual-Specificity Phosphatases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/*enzymology
MH  - Cell Membrane/enzymology
MH  - Cell Nucleus/enzymology
MH  - Cytosol/enzymology
MH  - Depression/*enzymology
MH  - Dual-Specificity Phosphatases
MH  - Enzyme Activation
MH  - Female
MH  - *Gene Expression
MH  - Hippocampus/enzymology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitogen-Activated Protein Kinase 1/analysis/*genetics/metabolism
MH  - Mitogen-Activated Protein Kinase 3
MH  - Mitogen-Activated Protein Kinase Phosphatases
MH  - Mitogen-Activated Protein Kinases/analysis/*genetics/metabolism
MH  - Phosphorylation
MH  - Prefrontal Cortex/enzymology
MH  - Protein Tyrosine Phosphatases/analysis/metabolism
MH  - RNA, Messenger/analysis
MH  - *Suicide
EDAT- 2001/05/02 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/05/02 10:00
PHST- 2001/05/02 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/05/02 10:00 [entrez]
AID - 10.1046/j.1471-4159.2001.00300.x [doi]
PST - ppublish
SO  - J Neurochem. 2001 May;77(3):916-28. doi: 10.1046/j.1471-4159.2001.00300.x.