PMID- 11333982
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20220409
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 411
IP  - 6833
DP  - 2001 May 3
TI  - BDNF controls dopamine D3 receptor expression and triggers behavioural 
      sensitization.
PG  - 86-9
AB  - Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a 
      polypeptidic factor initially regarded to be responsible for neuron 
      proliferation, differentiation and survival, through its uptake at nerve 
      terminals and retrograde transport to the cell body. A more diverse role for BDNF 
      has emerged progressively from observations showing that it is also transported 
      anterogradely, is released on neuron depolarization, and triggers rapid 
      intracellular signals and action potentials in central neurons. Here we report 
      that BDNF elicits long-term neuronal adaptations by controlling the 
      responsiveness of its target neurons to the important neurotransmitter, dopamine. 
      Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from 
      dopamine neurons is responsible for inducing normal expression of the dopamine D3 
      receptor in nucleus accumbens both during development and in adulthood. BDNF from 
      corticostriatal neurons also induces behavioural sensitization, by triggering 
      overexpression of the D3 receptor in striatum of hemiparkinsonian rats. Our 
      results suggest that BDNF may be an important determinant of pathophysiological 
      conditions such as drug addiction, schizophrenia or Parkinson's disease, in which 
      D3 receptor expression is abnormal.
FAU - Guillin, O
AU  - Guillin O
AD  - Unite de Neurobiologie et Pharmacologie Moleculaire, INSERM U 109, Centre Paul 
      Broca, 2ter rue d'Alesia, 75014 Paris, France.
FAU - Diaz, J
AU  - Diaz J
FAU - Carroll, P
AU  - Carroll P
FAU - Griffon, N
AU  - Griffon N
FAU - Schwartz, J C
AU  - Schwartz JC
FAU - Sokoloff, P
AU  - Sokoloff P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drd3 protein, mouse)
RN  - 0 (Drd3 protein, rat)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, Dopamine D3)
RN  - 46627O600J (Levodopa)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Dopamine/physiology
MH  - Frontal Lobe/physiology
MH  - Gene Targeting
MH  - Levodopa/pharmacology
MH  - Male
MH  - Mice
MH  - Mutation
MH  - Neurons/physiology
MH  - Nucleus Accumbens/*physiology
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/metabolism
MH  - Receptors, Dopamine D2/*biosynthesis
MH  - Receptors, Dopamine D3
MH  - Ventral Tegmental Area/physiology
EDAT- 2001/05/03 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/05/03 10:00
PHST- 2001/05/03 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/05/03 10:00 [entrez]
AID - 35075076 [pii]
AID - 10.1038/35075076 [doi]
PST - ppublish
SO  - Nature. 2001 May 3;411(6833):86-9. doi: 10.1038/35075076.